An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains

Gram-negative bacteria were reported as a significant cause of infections in both community and nosocomial settings. Considered as one of the greatest threats to public health, the spread of bacteria drug resistance and the lack of effective alternative treatment options remains problematic. Herein, we report a promising strategy to combat Gram-negative resistant strains consisting of the combination of a macrolide antibiotic with a polyaminoisoprenyl adjuvant derivative leading to a significant decrease of antibiotic resistance.

Automated summary

Gram-negative bacteria pose a significant threat to public health due to the spread of drug resistance and the lack of effective alternative treatments. This study presents a promising strategy to combat resistant strains by combining a macrolide antibiotic with a polyaminoisoprenyl adjuvant derivative, resulting in a significant decrease in antibiotic resistance.