4.7 Article

Progesterone Receptor Modulates Extraembryonic Mesoderm and Cardiac Progenitor Specification during Mouse Gastrulation

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI

Xuefeng Ai et al.

Summary: Cell-based therapies for heart repair after myocardial infarction (MI) often suffer from poor cell viability and engraftment rates. This study successfully promoted the survival of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) by transiently overexpressing Vascular Endothelial Growth Factor (VEGF) mRNA, leading to improved therapy outcomes in the infarcted area.

MOLECULAR THERAPY (2023)

Article Genetics & Heredity

Systematic reconstruction of cellular trajectories across mouse embryogenesis

Chengxiang Qiu et al.

Summary: This article comprehensively describes the cellular trajectories of mammalian development by integrating multiple single-cell RNA sequencing datasets. It also identifies transcription factors as candidate regulators of each cell type's specification and finds cell-type homologs across vertebrate evolution.

NATURE GENETICS (2022)

Article Developmental Biology

Mechanosignaling in vertebrate development

Stefano Piccolo et al.

Summary: Cell mechanics play a significant role in developmental biology, with recent discoveries in mechanotransduction shedding light on its influence on gene expression. Actomyosin contractility serves as an integrating platform between morphogens, lateral inhibition, and mechanosignaling. Supracellular pulling forces and changes in embryonic material contexture act as overarching mechanical organizers. The continuum of forces ultimately links self-organizing movements with cell fate in development and regeneration.

DEVELOPMENTAL BIOLOGY (2022)

Article Cell & Tissue Engineering

Capturing Cardiogenesis in Gastruloids

Giuliana Rossi et al.

Summary: It has been found that mouse embryonic stem cells can mimic early heart organogenesis steps and support the development of cardiovascular progenitors. This new platform tool can be used to study heart development in detail.

CELL STEM CELL (2021)

Article Cardiac & Cardiovascular Systems

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor

Choon Boon Sim et al.

Summary: Using single-nucleus RNA sequencing and functional validation studies, it was found that the progesterone receptor plays a key role in guiding sex-dependent transcriptional programs and maturation processes in cardiac cells.

CIRCULATION (2021)

Article Multidisciplinary Sciences

Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility

Mary C. Peavey et al.

Summary: The study revealed that overexpression of progesterone receptor PGR-B leads to relaxation of uterine muscles, prolonged gestational length, and increased incidence of labor dystocia, while overexpression of PGR-A increases uterine muscle contraction without affecting gestational length.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Medicine, General & Internal

Sporadic miscarriage: evidence to provide effective care

Arri Coomarasamy et al.

Summary: The physical and psychological effects of miscarriage are often underestimated, with diagnostic challenges leading to delays in care and increased anxiety. Recommendations for comprehensive miscarriage care include reporting annual aggregate data, providing effective ultrasound services, and investing in training for healthcare providers.

LANCET (2021)

Article Multidisciplinary Sciences

The role of epithelial progesterone receptor isoforms in embryo implantation

Rong Li et al.

Summary: The loss of uterine epithelial progesterone receptor (PGR) is crucial for embryo implantation in both humans and mice. This study reveals that the two major isoforms PGRA and PGRB disrupt embryo implantation through FOXO1 pathways in uterine epithelium, and both regulate the LIF-SGK1-FOXO1 signaling pathway.

ISCIENCE (2021)

Article Oncology

Progesterone promotes immunomodulation and tumor development in the murine mammary gland

Lauryn R. Werner et al.

Summary: Clinical studies have linked the use of progestins, synthetic progesterone, to an increased risk of breast cancer. However, the specific role of native progesterone signaling through the progesterone receptor in breast tumor formation remains poorly understood. Research suggests that progesterone can repress certain immune signaling pathways, potentially promoting tumor development in the mammary gland. This study investigated the effects of progesterone on immune cell populations in mouse mammary glands, as well as the impact of progesterone receptor overexpression on tumor formation and immune cell populations. The findings indicate that progesterone treatment and progesterone receptor overexpression are associated with inhibited immune responses, decreased immune cell populations, and an increased risk of mammary gland tumor development in mice.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Biotechnology & Applied Microbiology

Engineering islets from stem cells for advanced therapies of diabetes

Johanna Siehler et al.

Summary: Diabetes is a significant global health concern affecting millions of people, and advanced therapies utilizing stem cell differentiation and islet engineering may offer potential breakthroughs in treatment. Research in these areas could lead to improved understanding of pancreatic function and provide new insights into diabetes mechanisms.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Neurosciences

Neural stem cells derived from human midbrain organoids as a stable source for treating Parkinson's disease Midbrain organoid-NSCs (Og-NSC) as a stable source for PD treatment

Seung Won Kim et al.

Summary: The study successfully generated midbrain organoids from human pluripotent stem cells for preparing cells for Parkinson's disease therapy. These cells exhibited stable midbrain characteristics with low batch-to-batch variations, showing potential for clinical application due to their therapeutic capacities.

PROGRESS IN NEUROBIOLOGY (2021)

Review Biochemistry & Molecular Biology

Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant

Rachida Guennoun

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Developmental Biology

Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells

Pierre Osteil et al.

DEVELOPMENT (2019)

Article Multidisciplinary Sciences

A single-cell molecular map of mouse gastrulation and early organogenesis

Blanca Pijuan-Sala et al.

NATURE (2019)

Review Biochemistry & Molecular Biology

Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?

Ryan M. Marquardt et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

Mesoderm specification and diversification: from single cells to emergent tissues

Elisabetta Ferretti et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

Article Developmental Biology

Progesterone modulates microtubule dynamics and epiboly progression during zebrafish gastrulation

Stephanie Eckerle et al.

DEVELOPMENTAL BIOLOGY (2018)

Article Multidisciplinary Sciences

Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration

Hector Sanchez-Iranzo et al.

NATURE COMMUNICATIONS (2018)

Article Endocrinology & Metabolism

Sex dimorphic regulation of osteoprogenitor progesterone in bone stromal cells

Alexander Kot et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2017)

Review Developmental Biology

The many faces of Pluripotency: in vitro adaptations of a continuum of in vivo states

Sophie Morgani et al.

BMC DEVELOPMENTAL BIOLOGY (2017)

Review Developmental Biology

Lineage specification in the mouse preimplantation embryo

Claire Chazaud et al.

DEVELOPMENT (2016)

Article Cell & Tissue Engineering

A Simple and Robust Method for Establishing Homogeneous Mouse Epiblast Stem Cell Lines by Wnt Inhibition

Michihiko Sugimoto et al.

STEM CELL REPORTS (2015)

Article Cell Biology

The Dynamics of Morphogenesis in the Early Mouse Embryo

Jaime A. Rivera-Perez et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Review Medicine, General & Internal

Molecular determinants of context-dependent progesterone receptor action in breast cancer

Christy R. Hagan et al.

BMC MEDICINE (2014)

Article Medicine, Research & Experimental

Heart Fields and Cardiac Morphogenesis

Robert G. Kelly et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2014)

Article Endocrinology & Metabolism

Progesterone is critical for the development of mouse embryos

Cong Zhang et al.

ENDOCRINE (2014)

Review Endocrinology & Metabolism

Progesterone Action in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer

J. Julie Kim et al.

ENDOCRINE REVIEWS (2013)

Article Endocrinology & Metabolism

Rapid Impact of Progesterone on the Neuronal Growth Cone

Laura Olbrich et al.

ENDOCRINOLOGY (2013)

Article Genetics & Heredity

Activin-Like Kinase 2 Functions in Peri-implantation Uterine Signaling in Mice and Humans

Caterina Clementi et al.

PLOS GENETICS (2013)

Article Multidisciplinary Sciences

Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells

Alexandra Klaus et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Cell & Tissue Engineering

Isolation of Epiblast Stem Cells from Preimplantation Mouse Embryos

Fadi J. Najm et al.

CELL STEM CELL (2011)

Review Cell Biology

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

Sebastian J. Arnold et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Article Gastroenterology & Hepatology

Overexpression of progesterone receptor B increases sensitivity of human colon muscle cells to progesterone

Ling Cheng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Cardiac & Cardiovascular Systems

Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system

Martijn L. Bakker et al.

CIRCULATION RESEARCH (2008)

Review Anatomy & Morphology

Molecular and developmental biology of the hemangioblast

Jing-Wei Xiong

DEVELOPMENTAL DYNAMICS (2008)

Article Multidisciplinary Sciences

Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis

Alexandra Klaus et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Derivation of pluripotent epiblast stem cells from mammalian embryos

I. Gabrielle M. Brons et al.

NATURE (2007)

Article Developmental Biology

Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3

JA Rivera-Pérez et al.

DEVELOPMENTAL BIOLOGY (2005)

Review Biochemistry & Molecular Biology

Integrins: Bidirectional, allosteric signaling machines

RO Hynes

Article Multidisciplinary Sciences

Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse

T Fujiwara et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)