Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms23169355
Keywords
DYRK1A; protein kinase; neurodegenerative diseases; cancers; diabetes; viral infections; heart diseases
Funding
- Edson Family Foundation [38526]
- ADDF grants
- NIA [1R01NS109422-01A1]
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With the increasing aging population, finding therapeutic solutions for age-related diseases becomes crucial. Kinases play a pivotal role in human health and represent promising targets for drug development. DYRK1A, a protein implicated in various human diseases, has attracted significant attention for its potential therapeutic applications.
The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.
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