Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/ijms231810941
Keywords
helicobacter pylori; host cells; antimicrobial responses; antibiotic-resistance
Funding
- RGC-GRF Hong Kong [14107321]
- Heath and Medical Research Fund (HMRF) [18190951]
- National Natural Science Foundation of China (NSFC) [82103245]
- CUHK Direct Grant for Research [2021.004]
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This article focuses on the virulence factors necessary for the colonization and survival of H. pylori in the host gastric mucosa, as well as the host's antimicrobial responses to H. pylori infection. Additionally, the current treatments for H. pylori eradication are described, along with insights into new therapeutic strategies.
The colonization of Helicobacter pylori (H. pylori) in human gastric mucosa is highly associated with the occurrence of gastritis, peptic ulcer, and gastric cancer. Antibiotics, including amoxicillin, clarithromycin, furazolidone, levofloxacin, metronidazole, and tetracycline, are commonly used and considered the major treatment regimens for H. pylori eradication, which is, however, becoming less effective by the increasing prevalence of H pylori resistance. Thus, it is urgent to understand the molecular mechanisms of H. pylori pathogenesis and develop alternative therapeutic strategies. In this review, we focus on the virulence factors for H. pylori colonization and survival within host gastric mucosa and the host antimicrobial responses against H. pylori infection. Moreover, we describe the current treatments for H. pylori eradication and provide some insights into new therapeutic strategies for H. pylori infection.
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