Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/ijms23179795
Keywords
dry eye; inflammation; ocular surface; proteases; protease-activated receptors; protease inhibitor
Funding
- European Union [765608]
- University of Antwerp, SEP-BOF [44874, 44875]
- Marie Curie Actions (MSCA) [765608] Funding Source: Marie Curie Actions (MSCA)
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This review examines the implications of proteases in the development and severity of dry eye disease and discusses the progress in utilizing protease inhibitors as potential therapeutic tools.
Dry eye disease (DED) is a multifactorial disorder that leads to ocular discomfort, visual disturbance, and tear film instability. DED is accompanied by an increase in tear osmolarity and ocular surface inflammation. The diagnosis and treatment of DED still present significant challenges. Therefore, novel biomarkers and treatments are of great interest. Proteases are present in different tissues on the ocular surface. In a healthy eye, proteases are highly regulated. However, dysregulation occurs in various pathologies, including DED. With this review, we provide an overview of the implications of different families of proteases in the development and severity of DED, along with studies involving protease inhibitors as potential therapeutic tools. Even though further research is needed, this review aims to give suggestions for identifying novel biomarkers and developing new protease inhibitors.
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