Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media

The application of immobilized sulfuric acid on silica gel (H2SO4-SiO2) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel alpha-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts were obtained in high to excellent yields within 10 min in aqueous media under catalytic conditions. The key advantages of the process include a short reaction time, high yields, the catalyst's low cost, and the catalyst's reusability.

Automated summary

The application of immobilized sulfuric acid on silica gel as a solid catalyst in the synthesis of novel alpha-acyloxycarboxamide derivatives via a Passerini reaction was explored. The process showed advantages such as short reaction time, high yields, low cost, and catalyst reusability.