Post-Transcriptional Modifications of RNA as Regulators of Apoptosis in Glioblastoma

This review is devoted to changes in the post-transcriptional maturation of RNA in human glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The review thoroughly highlights the latest information on both post-transcriptional modifications of certain regulatory RNAs, associated with the process of apoptosis, presents data on the features of apoptosis in glioblastoma cells, and shows the relationship between regulatory RNAs and the apoptosis in tumor cells. In conclusion, potential target candidates are presented that are necessary for the development of new drugs for the treatment of glioblastoma.

Automated summary

This review focuses on the alterations in post-transcriptional maturation of RNA in human glioblastoma cells, which disrupts the normal process of apoptosis. The review provides a comprehensive overview of the latest insights into post-transcriptional modifications of specific regulatory RNAs associated with apoptosis, presents findings on the characteristics of apoptosis in glioblastoma cells, and highlights the connection between regulatory RNAs and apoptosis in tumor cells. In conclusion, potential target candidates for the development of new drugs for glioblastoma treatment are identified.