Journal
CARBOHYDRATE POLYMERS
Volume 134, Issue -, Pages 467-474Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.07.097
Keywords
Centrifugal electrospinning; High-throughput; Alignment; Nanofibers
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Funding
- NIH [NIH/NCI R01CA172455]
- Kyocera Professor Endowment
- National Science Foundation
- Ruth L. Kirschstein NIH Training grant [T32CA138312]
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The inability to produce large quantities of nanofibers has been a primary obstacle in advancement and commercialization of electrospinning technologies, especially when aligned nanofibers are desired. Here, we present a high-throughput centrifugal electrospinning (HTP-CES) system capable of producing a large number of highly-aligned nanofiber samples with high-yield and tunable diameters. The versatility of the design was revealed when bead-less nanofibers were produced from copolymer chitosan/polycaprolactone (C-PCL) solutions despite variations in polymer blend composition or spinneret needle gauge. Compared to conventional electrospinning techniques, fibers spun with the HTP-CES not only exhibited superior alignment, but also better diameter uniformity. Nanofiber alignment was quantified using Fast Fourier Transform (FM analysis. In addition, a concave correlation between the needle diameter and resultant fiber diameter was identified. This system can be easily scaled up for industrial production of highly-aligned nanofibers with tunable diameters that can potentially meet the requirements for various engineering and biomedical applications. (C) 2015 Elsevier Ltd. All rights reserved.
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