Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 40, Issue -, Pages 177-184Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2016.06.021
Keywords
Azidophenyl gelatin (Az-Gel); Bone morphogenetic protein-2 (BMP-2); Osteogenesis; Photo-immobilization; Rat calvarial defect model
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2013R1A1A2009322]
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Twenty-eight rats were randomized into two groups: a control group comprising a collagen sheet with only cast BMP-2; and an experimental group comprising a collagen sheet with BMP-2 photo immobilized using azidophenyl gelatin. Micro-computed tomography analysis revealed that there was more regenerated bone in experimental group at both 4 and 8 weeks. Immunohistochemical analysis revealed that the positively expressed cellular ratio in RUNX2-stained cells were significantly higher in experimental group. These results demonstrate that BMP-2 photo-immobilized using Az-Gel on a collagen sheet shows promising bone regeneration, and the sheet is a good candidate of BMP-2 carrier. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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