Journal
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
Volume 246, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ijheh.2022.114048
Keywords
Passive smoking; Cotinine; Polycyclic aromatic hydrocarbons; Oxidative stress
Funding
- National Institute of Environmental Health Sciences (NIEHS)
- National Natural Science Foundation of China
- UCLA center for Occupational and Environmental Health
- [1R21ES024560]
- [21876002]
- [41561144007]
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There is significant heterogeneity in smoking prevalence and tobacco control policy across different countries, which may lead to increased passive smoking and adverse health effects among international travelers. This pilot study found that traveling to a city with higher smoking prevalence may increase passive smoking exposure, with pro-oxidative effects partially mediated by polycyclic aromatic hydrocarbons (PAHs).
There is a great heterogeneity in smoking prevalence and tobacco control policy across different countries. However, it is unknown whether this heterogeneity could cause increased passive smoking and adverse health effects among international travelers. In this pilot study, we collected 190 urine samples from 26 Los Angeles residents before (LA-before), during (Beijing), and after (LA-after) a 10-week visit to Beijing to measure bio-markers of passive smoking (cotinine), exposure to polycyclic aromatic hydrocarbons (OH-PAHs), and oxidative stress (malondialdehyde, 8-isoprostane, and uric acid). The geometric mean concentrations of urinary cotinine were 0.14, 1.52, and 0.22 mu g/g creatinine in LA-before, Beijing, and LA-after, respectively. Likewise, OH-PAH levels were significantly higher in Beijing as compared to LA-before or LA-after, in association with the uri-nary cotinine levels. One-fold increase in urinary cotinine levels was associated with 10.1% (95% CI: 5.53-14.8%), 8.75% (95% CI: 2.33-15.6%), and 25.4% (95%CI: 13.1-39.1%) increases in urinary levels of malondialdehyde, 8-isoprotane, and uric acid, respectively. OH-PAHs mediated 9.1-23.3% of the pro-oxidative effects associated with passive smoking. Taken together, our findings indicate that traveling to a city with higher smoking prevalence may increase passive smoking exposure, in association with pro-oxidative effects partially mediated by PAHs.
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