Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 37, Issue -, Pages 101-106Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2016.03.014
Keywords
PLGA; Hollow porous microspheres; Sucrose; Dexamethasone; BMP2
Funding
- National Research Foundation of Korea (NRF) grants - MSIP [NRF-2013R1A2A1A09013980, NRF-2015R1A5A1037656]
- MEST [NRF-2014R1A6A3A04055123]
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Hollow porous poly(D,L-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Coll) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Coll. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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