Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 34, Issue -, Pages 33-40Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2015.10.025
Keywords
Implant coating material; Low molecular weight O-carboxymethyl; Chitosan derivative; Titanium; Photo-immobilization
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and future planning [NRF-2014R1A2A1A11052623]
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The purpose of this study is to immobilize growth factors and coat titanium surfaces using phosphonated UV-curable low-molecular-weight chitosan (Az-P-LM-O-CMC). The structure of the final product was assessed with FT-IR, P-31-NMR, and GPC. The coating of Az-P-LM-O-CMC on titanium was evaluated by measuring water contact angle. Cytotoxicity testing was conducted to determine biocompatibility, and micropatterning was used to check protein immobilization. From the BMP-2 release tests, it was observed that the rate of BMP-2 release could be controlled by multilayer coatings. ALP assay and Ca2+ assay were carried out to evaluate drug immobilization and release effects. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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