Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 33, Issue -, Pages 185-189Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2015.10.001
Keywords
Gold nanoparticles; Casein hydrolytic peptides; Anti-cancer assessment; Green chemistry; Cytotoxicity assay
Funding
- Human Resource Training Program for Regional Innovation and Creativity through the Ministry of Education and National Research Foundation (NRF) of Korea [NRF-2014H1C1A1066929]
- ME [NRF-2013R1A1A4A01008000, NRF-2009-0093819]
- NRF - Korea government (MSIP) [NRF-2015M2A7A1000194]
- NRF of Korea
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This study demonstrates casein hydrolytic peptide (CHP)-mediated synthesis of crystalline gold nanoparticles (AuNPs). The AuNPs formation was triggered by the addition of an aqueous NaOH solution due to the catalytic properties of OH- and/or hydration of the functional groups of CHPs. The CHPs were capable of forming a monolayer on the AuNP surface via electrostatic interactions, thus playing an important role in long-term stability (12 months). The AuNPs resulted in lower viability in the human prostate cancer cell line as compared to the normal mouse hepatocyte cell line; this property exhibits the potential of AuNPs for applications in cancer therapy. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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