Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 222, Issue -, Pages 2065-2071Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.10.005
Keywords
Sargassum fusiforme; Fucoidan; Inflammation
Funding
- Qingdao Postdoctoral Applied Research Project [862105040061]
- Ocean University of China [862101013159]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2019R1A6A1A03033553]
- Qingdao International Innovation Cooperation Project for Science and Technology [22-3-6-ghgg-1-hz]
- Key R & D Program of Hainan Province [ZDYF2022XDNY189]
- Science and Technology Project of Qingdao Special Fund for the Benefiting-People Program [20-3-4-31-nsh]
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This study evaluated the anti-inflammatory effects of SFF-PS-F5 fucoidan extracted from fermented Sargassum fusiforme. The results from in vitro and in vivo experiments demonstrate that SFF-PS-F5 effectively inhibits inflammatory responses, suggesting its potential as a functional ingredient in the food and cosmetic industries.
Fucoidans possess potent anti-inflammatory effects. In the present study, the anti-inflammatory effect of the fucoidan (SFF-PS-F5) isolated from fermented Sargassum fusiforme was evaluated in vitro in RAW 264.7 macro-phages and in vivo in zebrafish. The in vitro test results demonstrate that SFF-PS-F5 effectively inhibited nitric oxide (NO) production induced by lipopolysaccharides (LPS) in RAW 264.7 cells. SFF-PS-F5 effectively and concentration-dependently improved the viability of LPS-stimulated RAW 264.7 cells, and reduced the level of prostaglandin E2, interleukin-1 beta, tumor necrosis factor-alpha, and interleukin-6. Further results display that these effects were actioned by suppressing the expression of inducible nitric oxide synthase and cyclooxygenase-2 via regulating the nuclear factor kappa-B signaling pathway. The in vivo test results indicate that SFF-PS-F5 remarkably reduced reactive oxygen species, cell death, and NO levels in LPS-treated zebrafish. These results indicate that SFF-PS-F5 could inhibit both in vitro and in vivo inflammatory responses and suggest it is a func-tional ingredient in the functional food and cosmetic industries.
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