Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 218, Issue -, Pages 720-738Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.07.158
Keywords
Mechanism; Polysaccharides; Alzheimer's diseases
Funding
- School-level key project of Ningxia Medical University [XZ2020005]
- Seventh batch of national traditional Chinese medicine experts academic experience inheritance project
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This paper evaluated the effects and mechanisms of natural polysaccharides on Alzheimer's disease and summarized the extraction process and structure-activity relationship of polysaccharides.
Alzheimer's disease (AD), a neurodegenerative disease with insidious onset and progressive progression, is the main type of dementia. Currently, there is no specific cure for the disease. At the same time, a series of drug developments based on the classic theory, the A beta cascade hypothesis, have not completed phase III clinical trials, challenging the hypothesis. Polysaccharides obtained from natural products can be used in the treatment of AD, which has attracted academic attention due to its advantages of multi-target, multi-channel, no or modest side effects. The TCM syndrome type of AD is mainly qi and blood deficiency, kidney essence deficiency, and the medicine is mainly used to replenish qi and blood, kidney and bone marrow. Thus, there has been extensive and in-depth research on polysaccharides obtained from tonic Chinese herbal medicine in China. Based on this background, this paper evaluated the effects and mechanisms of natural polysaccharides on AD by combing and screening English and related literature in recent 5 years and summarized the extraction process and structure-activity relationship of polysaccharides.
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