Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 218, Issue -, Pages 506-518Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.06.196
Keywords
Type -II diabetes; Wound healing; Hydrogel patch; High -fat -diet; Guar gum; ROS management
Funding
- UGC-SRF fellowship
- ICMR-SRF fellowship
- UGC-JRF fellowship
- DST-SUTRAM project [GAP-375]
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A Guar Gum-based macroporous hydrogel infused with antibacterial agent and antioxidant can promote wound healing and inhibit bone infection in a high-fat-diet-induced diabetes mice model. The hydrogel facilitates scar-free wound healing through enhanced cell proliferation, tissue fiber formation, void space reduction, and re-epithelialization.
Delayed wound healing in patients having type-II diabetes mellitus (T2DM) often results in a high rate of amputation. We report an innovative Guar Gum-based macroporous hydrogel (HG) infused with an antibacterial agent (Ag NPs), and antioxidant, epigallocatechin gallate (EGCG) to address rapid wound healing and interestingly could inhibit the associated pathophysical bone infection in a high-fat-diet-induced T2DM C57BL/6 mice model. The HG-Ag-EGCG elicits scar-free wound healing in subcutaneous wounds and histopathological evidence confirmed HG-Ag-EGCG hydrogel patch elicits better wound healing through enhanced cell proliferation, mature connecting tissue fiber formation, minimum void spaces formation, and better re-epithelialization when compared with a market available hydrogel patch material (Luofucon (R)). Supportive of the in vivo outcomes, in vitro experiments delineated better-wound closure due to improved management of ROS by the HG-Ag-EGCG. Additionally, a favorable non-toxicity outcome assessed through both in vitro and in vivo conditions confirmed its potential applicability in clinical wound care management.
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