Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 220, Issue -, Pages 1345-1355Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.09.029
Keywords
O-acetyl-glucomannan; Selenization modification; Antitumor activity; Platycodon grandiflorum; Zebrafish xenograft model
Funding
- National Natural Science Foundation of China [22277059, U1801288, 22077067]
- National Key Research and Development Program of China [2018YFA0507204]
- 111 Project [B20016]
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Acetylated glucomannan (PGP40-1) purified from Platycodon grandiflorum showed weak antitumor activity, which was enhanced after modification to selenized polysaccharide (Se-PGP40-1).
Platycodon grandiflorum is consumed popularly as a nutritional and healthy plant in East Asia, which has multiple medicinal functions. As an exploration to elucidate the beneficial ingredients, an acetylated glucomannan (PGP40-1) was purified from P. grandiflorum. Structural analysis showed that PGP40-1 was composed of -> 4)-beta-Manp-(1 ->, -> 4)-beta-Glcp-(1 ->, -> 6)-beta-Glcp-(1 ->, and terminal alpha-Glcp-(1 ->. PGP40-1 was found to possess weak antitumor activity in vitro, which was thus modified to afford a selenized polysaccharide (Se-PGP40-1) by the HNO3/Na2SeO3 method. Se-PGP40-1 showed significant antitumor activity in cell and zebrafish models, which could inhibit tumor proliferation and migration by inducing cell apoptosis and blocking angiogenesis. The research not only clarifies the ingredients of P. grandiflorum with high economical value, but also affords a potential antitumor agent originating from the plant polysaccharide.
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