4.7 Article

Dual-modified starch micelles as a promising nanocarrier for doxorubicin

Journal

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 219, Issue -, Pages 685-693

Publisher

ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.07.141

Keywords

Nanocarrier; Micelle; Corn starch; Deoxycholic acid; Sustained release

Funding

  1. Agriculture Research System of China [CARS-170502]
  2. Science and Technology of Guangxi Zhuang Autonomous [AA17204092, AB19110054]
  3. Natural Science Foundation of Guangxi Province [2021JJA160287]
  4. Innovation Project of Guangxi Graduate Education [YCBZ2020018]

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This study successfully synthesized biocompatible dual-modified starch micelles and demonstrated their potential as drug delivery vehicles. The results provide reference information for further research in biotechnology and pharmaceutical domains.
Natural amphiphilic polymer micelles have garnered considerable research attention as nanocarriers for delivering drugs. The objective of this study was to explore the possibility of applying biocompatible dual-modified starch micelles as drug delivery vehicles. To this end, a dual-modified corn starch polymer (SCD) was synthesized with zwitterionic sulfobetaine and deoxycholic acid; spherical micelles with an average particle size of similar to 200 nm were prepared through the self-assembly of SCD. The effects of dual modification on the degree of substitution, molecular structure, and functional properties of SCD were investigated. Further, doxorubicin was successfully incorporated into the micelles, and an in vitro drug release study was performed to confirm that the drug-loaded micelles displayed pH-sensitive properties with controlled and sustained release. The dissolve-diffuse-erosion-degradation release process was described according to the dynamic models of drug release for SCD micelles. The results can be used as reference information for further studies in the biotechnology and pharmaceutical domains.

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