Journal
JOURNAL OF IMMUNOLOGY
Volume 196, Issue 9, Pages 3542-3546Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1502614
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Funding
- National Multiple Sclerosis Society Grants [FG 2019, RG 4486]
- National Institutes of Health [R21 NS077116, R01 NS081687]
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The neutralization of integrin alpha(4) (Itga4) is currently used as treatment in multiple sclerosis. Although most studies have focused on its function on lymphocyte migration to the CNS, we have uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology. Our study underscores the importance of looking at the dual role of B cells in CNS autoimmunity and provides important perspectives regarding the efficacy and side effects associated with Itga4 neutralization and other B cell-targeting therapies.
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