Journal
JOURNAL OF IMMUNOLOGY
Volume 197, Issue 11, Pages 4325-4333Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1600642
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Funding
- National Institutes of Health [R01AI097392]
- National Multiple Sclerosis Society [RG4654]
- University Cancer Research Fund
- Cancer Center Core Support [P30 CA016086]
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Bromodomain PHD finger transcription factor (BPTF), a ubiquitously expressed ATP-dependent chromatin-remodeling factor, is critical for epigenetically regulating DNA accessibility and gene expression. Although BPTF is important for the development of thymocytes, its function in mature T cells remains largely unknown. By specifically deleting BPTF from late double-negative 3/ double-negative 4 stage of developing T cells, we found that BPTF was critical for the homeostasis of T cells via a cell-intrinsic manner. In addition, BPTF was essential for the maintenance and function of regulatory T (Treg) cells. Treg cell specific BPTF deletion led to reduced Foxp3 expression, increased lymphocyte infiltration in the nonlymphoid organs, and a systemic autoimmune syndrome. These findings therefore reveal a vital role for BPTF in T and Treg cell function and immune homeostasis.
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