Journal
JOURNAL OF IMMUNOLOGY
Volume 196, Issue 4, Pages 1591-1603Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1500805
Keywords
-
Categories
Funding
- National Special Research Program for Important Infectious Diseases [2013ZX10001004]
- Guangdong Innovative Research Team Program [2009010058]
- National Basic Research Program of China (973 Program) [2010CB912202]
- National Natural Science Foundation of China [30972620]
Ask authors/readers for more resources
The discovery of PIWI-interacting RNAs (piRNAs) revealed the complexity of the RNA world. Although piRNAs were first deemed to be germline specific, substantial evidence shows their various roles in somatic cells; however, their function in highly differentiated immune cells remains elusive. In this study, by initially screening with a small RNA deep-sequencing analysis, we found that a piRNA, tRNA-Glu-derived piRNA [td-piR(Glu)], was expressed much more abundantly in human monocytes than in dendritic cells. By regulating the polymerase III activity, IL-4 potently decreased the biogenesis of tRNA-Glu and, subsequently, td-piR(Glu). Further, we revealed that the td-piR(Glu)/PIWIL4 complex recruited SETDB1, SUV39H1, and heterochromatin protein 1 beta to the CD1A promoter region and facilitated H3K9 methylation. As a result, the transcription of CD1A was significantly inhibited. Collectively, we demonstrated that a piRNA acted as the signal molecule for a cytokine to regulate the expression of an important membrane protein for lipid Ag presentation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available