Blockade of PD-1/PD-L1 increases effector T cells and aggravates murine chronic graft-versus-host disease

Article Surgery

PD-1 antibody and ruxolitinib enhances graft-versus-lymphoma effect without increasing acute graft-versus-host disease in mice

Bin Pan et al.

Summary: The combined therapy of PD-1 antibody and ruxolitinib increased graft-versus-lymphoma effects without increasing acute graft-versus-host disease, leading to improved survival of recipients challenged by A20 lymphoma cells.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Medicine, Research & Experimental

Dynamic of plasma IL-22 level is an indicator of thymic output after allogeneic hematopoietic cell transplantation

Longmei Shang et al.

Summary: This study found a positive correlation between plasma IL-22 levels and blood TRECs levels at days 14 and 28 posttransplant in humans. Higher plasma IL-22 levels, occurrence of aGVHD, and age were significantly associated with higher blood TRECs levels at day 28 after allotransplant. An increase in plasma IL-22 levels during days 14 and 28 was linked to faster recovery of blood TRECs and naive T-cell levels in recipients. High TRECs levels at day 28 were associated with lower incidence of aGVHD, regardless of IL-22 levels. Other factors like age and infection also impacted plasma IL-22 levels in allotransplant recipients.

LIFE SCIENCES (2021)

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Article Dermatology

IFN-γ-Stimulated Apoptotic Keratinocytes Promote Sclerodermatous Changes in Chronic Graft-Versus-Host Disease

Akimasa Saito et al.

Summary: In patients with GVHD, KCs in skin lesions of chronic GVHD show marked production of TGF beta 1, while IFN-gamma-deficient CD8 T-cell recipients have lower expression of TGF beta 1 in the epidermis. IFN-gamma promotes TGF beta 1 production by apoptotic KCs, mediating the development of widespread sclerodermatous changes in KC-targeting GVHD.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Hematology

Relevance of Plasma Matrix Metalloproteinase-9 for Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplantation

Yoshihiro Inamoto et al.

Summary: This study found that MMP-9 and MMP-3 concentrations were higher in patients with BOS after allogeneic HCT, while YKL-40 concentrations did not differ significantly among the groups. The study suggests that plasma MMP-9 concentration may serve as a relevant biomarker for survival prognosis and treatment response prediction in BOS patients after allogeneic HCT.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

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Review Medicine, Research & Experimental

Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease

Gerard Socie et al.

Summary: In the past 15 years, understanding of the pathophysiologic mechanisms underlying GVHD has significantly improved, but translation to clinical care has been slow and the clinical utility of new therapeutic agents has been inconsistent. New tools in immunology have recently been applied in the field of clinical GVHD, but there is a relative paucity of mechanistic insights into human translational research.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Hematology