Journal
INTERNATIONAL DAIRY JOURNAL
Volume 133, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.idairyj.2022.105436
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Funding
- Japan Society for the Promotion of Science [22K16379]
- Japan Agency for Medical Research and Development [20he0622015h0001]
- Kohjin Bio Co., Ltd
- Aotearoa Co., Ltd
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Bovine whey IgG enriched fraction contains antibodies against spike proteins of various SARS-CoV-2 variants, including omicron.
Bovine whey IgG enriched fraction contains IgG antibodies against bacterial and viral pathogens, including antibodies against the spike protein [amino acids (aa) 1-1274] of SARS-CoV-2 Wuhan strain (2019-nCoV WHU01). To date, 13 SARS-CoV-2 variants have been identified, including gamma, delta, kappa, and omicron, which contain 10, eight, seven, and over 30 mutations in the spike protein, respectively. We investigated whether bovine whey IgG enriched fraction contains antibodies against spike proteins of these variants, specifically recombinant partial length spike proteins (aa 177-512, aa 509-685, aa 177-324, aa 250-410 and aa 387-516) of these variants. Direct enzyme-linked immuno-sorbent assays revealed bovine whey IgG enriched fraction contained antibodies against all recombinant spike proteins of these variants with highest reactivity against aa 177-512 region of omicron spike protein. These results indicate bovine whey IgG enriched fraction contains antibodies against spike proteins of several SARS-CoV-2 variants, including omicron. (c) 2022 Elsevier Ltd. All rights reserved.
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