Journal
JOURNAL OF IMMUNOLOGY
Volume 196, Issue 5, Pages 2051-2062Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1501491
Keywords
-
Categories
Funding
- Crohn's and Colitis Foundation of America
- Juvenile Diabetes Research Foundation Cooperative Center for Cell Therapy
- Merck Scleroderma Research Fund at Benaroya Research Institute
- National Institutes of Health [T32AR056969, UL1TR000423]
Ask authors/readers for more resources
Innate lymphoid cells (ILC) are a heterogeneous group of cellular subsets that produce large amounts of T cell-associated cytokines in response to innate stimulation in the absence of Ag. In this study, we define distinct patterns of surface marker and cytokine expression among the ILC subsets that may further delineate their migration and function. Most notably, we found that the subset previously defined as group 1 ILC (ILC1) contains CD4(+) CD8(-), CD4(-) CD8(+), and CD4(-) CD8(-) populations. Although all ILC1 subsets shared characteristics with Th1 cells, CD4(+) ILC1 also demonstrated significant phenotypic and functional heterogeneity. We also show that the frequencies of CD4(+) ILC1 and NKp44(+) group 3 ILC, but not CD4(-) ILC1 or group 2 ILC, are increased in the peripheral blood of individuals with systemic sclerosis (SSc), a disease characterized by fibrotic and vascular pathology, as well as immune dysregulation. Furthermore, we demonstrate that CD4(+) and CD4(-) ILC1 are functionally divergent based on their IL-6R alpha expression and that the frequency of IL-6Ra expression on ILC is altered in SSc. The distinct phenotypic and functional features of CD4(+) and CD4(-) ILC1 suggest that they may have differing roles in the pathogenesis of immune-mediated diseases, such as SSc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available