The in vitro anti-inflammatory activity of N-antipyrine-3,4-dichloromaleimide derivatives is due to an immunomodulatory effect on cytokines environment

Article Immunology

Isobavachalcone prevents osteoporosis by suppressing activation of ERK and NF-KB pathways and M1 polarization of macrophages

Xiangyu Wang et al.

Summary: Our study demonstrates that isobavachalcone (ISO) can prevent osteoporosis by inhibiting the activation of ERK and NF-KB signaling pathways, as well as M1 polarization of macrophages.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Pinosylvin Shifts Macrophage Polarization to Support Resolution of Inflammation

Konsta Kivimaki et al.

Summary: Research indicates that pinosylvin can shift macrophage polarization from the pro-inflammatory M1 phenotype towards the M2 phenotype, supporting resolution of inflammation and repair.

MOLECULES (2021)

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Article Chemistry, Medicinal

Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis

Liuhua Pei et al.

Summary: The study revealed that cynaroside can promote phenotypic transition of hepatic macrophages from M1 to M2, alleviating sepsis-induced liver inflammation. Results suggest that cynaroside has a novel role in modulating immunometabolic pathways through affecting pyruvate kinase M2-mediated glycolysis, which could be valuable in sepsis treatment.

FITOTERAPIA (2021)

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Article Biochemical Research Methods

Omics and Transgenic Analyses Reveal that Salvianolic Acid B Exhibits its Anti-Inflammatory Effects through Inhibiting the Mincle-Syk-Related Pathway in Macrophages

Jia Li et al.

Summary: Sal B inhibits LPS-induced inflammation by inhibiting the Mincle-Syk-PKC delta signaling pathway, promotes the transformation of macrophages from M1 to M2 polarization, and partially restores the altered lipid profiles of LPS-induced RAW 264.7 macrophages.

JOURNAL OF PROTEOME RESEARCH (2021)

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Article Multidisciplinary Sciences

flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions

Gang Hu et al.

Summary: flDPnn is a computational tool that provides accurate, fast and comprehensive disorder and disorder function predictions from protein sequences. Evaluation based on the CAID experiment and other test datasets demonstrates that flDPnn offers high predictive accuracy in predicting disorder, fully disordered proteins, and common disorder functions.

NATURE COMMUNICATIONS (2021)

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Review Plant Sciences

A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents

Narges Marefati et al.

Summary: Onion and its derivatives possess anti-inflammatory, antioxidant, and immunomodulatory effects, indicating their therapeutic value in treating diseases associated with oxidative stress, inflammation, and immune dysregulation.

PHARMACEUTICAL BIOLOGY (2021)

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Review Chemistry, Medicinal