Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 25, Issue 8, Pages 1270-1278Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201403992
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Funding
- National Research Foundation of South Korea: Mid-career scientist grant [2014002855]
- National Research Foundation of South Korea: molecular-level Interface Research Center [20090083525]
- Korea Healthcare Technology R&D Project from the Ministry of Health and Welfare [HI12C0005]
- Korea Health Promotion Institute [HI12C0005010015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0083525, 10Z20130012893, 2014R1A2A1A01002855] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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DNA has emerged as a novel material in many areas of materials science due to its programmability. Especially, DNA hydrogels have been studied to incorporate new functions into gels. To date, only a few methods have been developed for fabricating DNA hydrogels, such as the use of complementary sequences or covalent bond. Herein, it is demonstrated that one of the most well-known plant-derived polyphenols, tannic acid (TA), can form a DNA hydrogel which is named TNA hydrogel (TA + DNA). TA plays a role as a molecular glue by a new mode of action reversibly connecting between phosphodiester bonds, which is different from the crosslinking utilizing complementary sequences. TA intrinsically degrades due to ester bonds connecting between pyrogallol groups, causing a degradable DNA hydrogel. Furthermore, TNA gel is multifunctional in that the gel is extensible upon pulling and adhesive to tissues because of the rich polyphenol groups in TA (ten phenols per TA). Unexpectedly, TNA gel exhibits superior in vivo hemostatic ability that can be useful for biomedical applications. This new DNA hydrogel preparation method represents a new technique for fabricating a large amount of DNA-based hemostatic hydrogel without chemically modifying DNA or requiring the crosslinking by complementary sequences.
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