Anti-psoriasis activities of hydroxytyrosol on HaCaT cells under psoriatic inflammation in vitro

Background Psoriasis is a prevalent chronic inflammatory dermatosis, which can significantly impact life quality of patients. The treatment of psoriasis is no cure and novel therapeutic options are urgently needed. Hydroxytyrosol (HT) possesses multiple biological activities, such as anti-inflammatory and anti-proliferation properties, suggesting its potential to counteract hallmarks of psoriasis. However, its role in the regulation of psoriasis remains unknown. Objective In the current study, we explored the anti-proliferative activity and anti-inflammatory responses of HT in psoriatic keratinocytes in vitro. Methods We used M5 cytokines cocktail, which includes tumor necrosis factor (TNF)-alpha, oncostatin-M, interleukin (IL)-17A, IL-1 alpha, and IL-22, to simulate HaCaT cells to establish the cell model of psoriasis and explore the effects of HT on psoriasis in vitro. Results This study showed that HT exerted potent anti-inflammatory effect via influencing the expression of IL-6, IL-8, and TNF-alpha in M5-induced cell model of psoriasis. Moreover, it suppressed the expression of antimicrobial proteins in psoriatic keratinocytes. Additionally, it inhibited cell proliferation in psoriasis cell model. Conclusions Altogether, our results suggested that HT has anti-psoriasis effects in vitro and HT may be a promising therapeutic agent in psoriasis treatment.

Automated summary

This study explored the anti-proliferative activity and anti-inflammatory responses of hydroxytyrosol (HT) in psoriatic keratinocytes. The results showed that HT exerted potent anti-inflammatory effects and inhibited cell proliferation in psoriasis cell model. This suggests that HT may be a promising therapeutic agent in psoriasis treatment.