Fooling TLR4 to promote fungal virulence

The invasive fungal pathogen Cryptococcus neoformans promotes type 2 immunity to escape host defenses by unknown mechanisms. In a recent issue of Nature, Dang and colleagues identify a secreted fungal protein that triggers TLR4 signaling and supports a type 2 permissive environment and C. neoformans growth.

Automated summary

The invasive fungal pathogen Cryptococcus neoformans promotes type 2 immunity to escape host defenses by unknown mechanisms. In a recent study, researchers identify a secreted fungal protein that triggers TLR4 signaling, supporting a type 2 permissive environment and growth of C. neoformans.