Journal
IMMUNITY
Volume 55, Issue 9, Pages 1515-1529Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2022.08.002
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Funding
- ERC [851908, 725924]
- CZI
- FWO
- Ghent University
- European Research Council (ERC) [725924, 851908] Funding Source: European Research Council (ERC)
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Single-cell and spatial transcriptomic technologies have uncovered the heterogeneity of liver macrophages, which is crucial for understanding their roles in liver homeostasis and disease.
Single-cell and spatial transcriptomic technologies have revealed an underappreciated heterogeneity of liver macrophages. This has led us to rethink the involvement of macrophages in liver homeostasis and disease. Identification of conserved gene signatures within these cells across species and diseases is enabling the correct identification of specific macrophage subsets and the generation of more specific tools to track and study the functions of these cells. Here, we discuss what is currently known about the definitions of these different macrophage populations, the markers that can be used to identify them, how they are wired within the liver, and their functional specializations in health and disease.
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