Journal
CARBOHYDRATE POLYMERS
Volume 117, Issue -, Pages 384-391Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.09.077
Keywords
fouling; Zwitterionic; Hydrogel; Starch Hydrogen bonding hydration; Ionic solvation hydration
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Funding
- National Nature Science Foundation of China [51073119, 31271016, 31370975, 81101448]
- Ministry of Science and Technology of China [2013DFG52040]
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Non-fouling materials bind water molecules via either hydrogen bonding or ionic solvation to form a hydration layer which is responsible for their resistance to protein adsorption. Three ionic starch-based polymers, namely a cationic starch (C-Starch), an anionic starch (A-Starch) and a zwitterionic starch (Z-Starch), were synthesized via etherification reactions to incorporate both hydrogen bonding and ionic solvation hydration groups into one molecule. Further, C-, A- and Z-Starch hydrogels were prepared via chemical crosslinking. The non-fouling properties of these hydrogels were tested with different proteins in solutions with different ionic strengths. The C-Starch hydrogel had low protein resistance at all ionic strengths; the A-Starch hydrogel resisted protein adsorption at ionic strengths of more than 10 mM; and the Z-Starch hydrogel resisted protein adsorption at all ionic strengths. In addition, the A- and ZStarch hydrogels both resisted cell adhesion. This work provides a new path for developing non-fouling materials using the integration of polysaccharides with anionic or zwitterionic moieties to regulate the protein resistance of materials. (C) 2014 Elsevier Ltd. All rights reserved.
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