4.5 Article

Engineering Cancer Selective Virotherapies: Are the Pieces of the Puzzle Falling into Place?

Related references

Note: Only part of the references are listed.
Article Neurosciences

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

David Goertsen et al.

Summary: The study developed AAV capsids that achieved robust transgene expression in the brain with decreased liver targeting after non-invasive administration, enabling more targeted systemic gene delivery. This organ-specific targeting extends to marmosets, allowing for non-invasive gene delivery with distinct transgene expression patterns. The ability to cross the blood-brain barrier with neuronal specificity in rodents and non-human primates opens up new avenues for basic research and therapeutic possibilities beyond naturally occurring serotypes.

NATURE NEUROSCIENCE (2022)

Review Neurosciences

Adeno-Associated Virus Toolkit to Target Diverse Brain Cells

Rosemary C. Challis et al.

Summary: Researchers have developed an AAV toolkit with engineerable capsid and cargo to achieve molecular access to defined brain cell types. By pairing these AAVs with gene regulatory elements and cargo, highly specific transgene expression in specific neuronal cell types can be achieved.

ANNUAL REVIEW OF NEUROSCIENCE (2022)

Article Oncology

Development of a low-seroprevalence, avb6 integrin-selective virotherapy based on human adenovirus type 10

Emily A. Bates et al.

Summary: Oncolytic virotherapies based on human adenoviruses show great clinical potential. Incorporating a peptide that selectively targets alpha v beta 6 integrin, the HAdV-D10 serotype vector can effectively target alpha v beta 6-positive tumor cells. Structural and biological studies show that HAdV-D10 has weak interactions with adenoviral receptors and does not engage blood coagulation factor X, reducing off-target hepatice sequestration. In vitro and in vivo experiments demonstrate that HAdV-D10.A20 selectively kills cancer cells and has significant potential for clinical translation.

MOLECULAR THERAPY-ONCOLYTICS (2022)

Article Oncology

Superior infectivity of the fiber chimeric oncolytic adenoviruses Ad5/35 and Ad5/3 over Ad5-delta-24-RGD in primary glioma cultures

Aleksei A. Stepanenko et al.

Summary: Ad5-delta-24-RGD is the most clinically advanced recombinant adenovirus for glioma therapy. Different fiber-modified rAds were constructed and compared, showing that Ad5/35-delta-24 and Ad5/3-delta-24 exhibited superior infectivity and cytolytic efficacy compared to Ad5-delta-24-RGD. The expression of adenoviral receptors/coreceptors and integrins did not predict the cytolytic efficacy of the fiber-modified rAds. CT-2A and GL261 glioma cells were identified as murine cell models for studying fiber chimeric rAds. Ad5/35-delta-24 armed with the immune costimulator OX40L demonstrated potential for glioblastoma treatment.

MOLECULAR THERAPY-ONCOLYTICS (2022)

Review Biochemistry & Molecular Biology

Human organoids: New strategies and methods for analyzing human development and disease

Nina S. Corsini et al.

Summary: For a long time, animal models have been the primary means of gaining insight into the fundamental principles of human biology and disease. However, due to species differences, some developmental and disease mechanisms have been challenging to study. The advent of organoid technology over a decade ago has provided a new model system to investigate human-specific aspects of biology. The use of human 3D organoids, along with advancements in single-cell technologies, has revealed unprecedented insights into human biology and disease mechanisms.
Review Microbiology

Fantastic AAV Gene Therapy Vectors and How to Find Them-Random Diversification, Rational Design and Machine Learning

Jonas Becker et al.

Summary: Parvoviruses, a family of small DNA viruses, have shown potential as gene delivery vectors for gene therapy. Researchers have made progress in enhancing and restricting in vivo transgene expression by modifying the capsid of the virus. Traditional and novel directed evolution approaches, as well as programmable receptor-mediated targeting, have been used to create new variants with higher specificity and efficiency of gene transfer.

PATHOGENS (2022)

Article Biotechnology & Applied Microbiology

The clinical landscape for AAV gene therapies

Dmitry A. Kuzmin et al.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Cell Biology

Enhancer grammar in development, evolution, and disease: dependencies and interplay

Granton A. Jindal et al.

Summary: The text discusses how biologists study the grammatical rules related to enhancer sequences and gene expression by searching for principles governing their relationship, in order to decipher the instructions within genomes and identify potentially disease- and evolution-related enhancer variants.

DEVELOPMENTAL CELL (2021)

Review Immunology

Pouring petrol on the flames: Using oncolytic virotherapies to enhance tumour immunogenicit

Alicia Teijeira Crespo et al.

Summary: This article reviews the potential of oncolytic viruses and immunotherapy combinations for enhancing cancer treatment efficacy. It also discusses the use of increasingly sophisticated model systems, particularly ex vivo patient-derived models, for preclinical assessment of these advanced agents.

IMMUNOLOGY (2021)

Article Virology

Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5NULL-A20

James A. Davies et al.

Summary: The study developed a tumor-selective adenovirus, Ad5(NULL)-A20, targeting alpha v beta 6 integrin-positive tumors, demonstrating selective transduction and cell killing effects. Following intravenous administration, biodistribution analysis in mice with breast cancer xenografts showed reduced liver accumulation and increased tumor accumulation with Ad5(NULL)-A20 compared to traditional Ad5, leading to improved tumor-to-liver ratios.

VIRUSES-BASEL (2021)

Article Cell Biology

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

John K. Mich et al.

Summary: By utilizing comparative open chromatin analysis and molecular profiling, specific gene expression in target brain cell types can be achieved, revolutionizing basic neuroscience and targeted gene therapy. This technology represents a collection of viral genetic tools that can control gene expression across different species, demonstrating potential therapeutic applications.

CELL REPORTS (2021)

Review Genetics & Heredity

Engineering adeno-associated virus vectors for gene therapy

Chengwen Li et al.

NATURE REVIEWS GENETICS (2020)

Review Oncology

Delivery and Biosafety of Oncolytic Virotherapy

Lizhi Li et al.

FRONTIERS IN ONCOLOGY (2020)

Review Immunology

Localized Interleukin-12 for Cancer Immunotherapy

Khue G. Nguyen et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Virology

Species D Adenoviruses as Oncolytic Viral Vectors

Brianna L. Bullard et al.

VIRUSES-BASEL (2020)

Review Oncology

Oncolytic Adenovirus in Cancer Immunotherapy

Malin Peter et al.

CANCERS (2020)

Article Biotechnology & Applied Microbiology

The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier

Juliette Hordeaux et al.

MOLECULAR THERAPY (2019)

Review Multidisciplinary Sciences

Cancer modeling meets human organoid technology

David Tuveson et al.

SCIENCE (2019)

Editorial Material Biotechnology & Applied Microbiology

Fighting Cancer with Viruses: Oncolytic Virus Therapy in China

Ding Wei et al.

HUMAN GENE THERAPY (2018)

Review Biotechnology & Applied Microbiology

The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic

Wei-Wei Zhang et al.

HUMAN GENE THERAPY (2018)

Review Oncology

Designer Oncolytic Adenovirus: Coming of Age

Alexander T. Baker et al.

CANCERS (2018)

Review Oncology

Organoids in cancer research

Jarno Drost et al.

NATURE REVIEWS CANCER (2018)

Article Chemistry, Multidisciplinary

Adeno-associated virus (AAV) vectors in cancer gene therapy

Jorge L. Santiago-Ortiz et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Article Biotechnology & Applied Microbiology

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

Benjamin E. Deverman et al.

NATURE BIOTECHNOLOGY (2016)

Article Biotechnology & Applied Microbiology

Retargeting Adenovirus Serotype 48 Fiber Knob Domain by Peptide Incorporation

Lynda Coughlan et al.

HUMAN GENE THERAPY (2014)

Article Medicine, Research & Experimental

Development of a Novel Efficient Method To Construct an Adenovirus Library Displaying Random Peptides on the Fiber Knob

Yuki Yamamoto et al.

MOLECULAR PHARMACEUTICS (2014)

Article Multidisciplinary Sciences

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Anoop P. Patel et al.

SCIENCE (2014)

Article Virology

AAV-Mediated Gene Therapy for Research and Therapeutic Purposes

R. Jude Samulski et al.

ANNUAL REVIEW OF VIROLOGY, VOL 1 (2014)

Editorial Material Oncology

Healing after death: antitumor immunity induced by oncolytic adenoviral therapy

Hong Jiang et al.

ONCOIMMUNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

Robert C. Muench et al.

MOLECULAR THERAPY (2013)

Article Multidisciplinary Sciences

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters

Birgit Dreier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Molecular evolution of human adenoviruses

Christopher M. Robinson et al.

SCIENTIFIC REPORTS (2013)

Review Genetics & Heredity

Transcription factors: from enhancer binding to developmental control

Francois Spitz et al.

NATURE REVIEWS GENETICS (2012)

Review Virology

Systemic Delivery of Oncolytic Viruses: Hopes and Hurdles

Mark S. Ferguson et al.

ADVANCES IN VIROLOGY (2012)

Article Biochemistry & Molecular Biology

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

Hongjie Wang et al.

NATURE MEDICINE (2011)

Article Biotechnology & Applied Microbiology

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

Kevin D. Foust et al.

NATURE BIOTECHNOLOGY (2009)

Article Biochemistry & Molecular Biology

Adenovirus serotype 5 hexon mediates liver gene transfer

Simon N. Waddington et al.

Article Multidisciplinary Sciences

Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer

Irene Kuhn et al.

PLOS ONE (2008)

Article Pharmacology & Pharmacy

Enhanced gene transfer activity of peptide-targeted gene-delivery vectors

AL Parker et al.

JOURNAL OF DRUG TARGETING (2005)

Review Biotechnology & Applied Microbiology

The influence of adenovirus fiber structure and function on vector development for gene therapy

SA Nicklin et al.

MOLECULAR THERAPY (2005)

Article Biotechnology & Applied Microbiology

Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates

J Lanciotti et al.

MOLECULAR THERAPY (2003)

Article Biotechnology & Applied Microbiology

In vivo hepatic adenoviral gene delivery occurs independently of the coxsackievirus-adenovirus receptor

T Smith et al.

MOLECULAR THERAPY (2002)

Article Biotechnology & Applied Microbiology

Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

A Kanerva et al.

MOLECULAR THERAPY (2002)

Article Biochemistry & Molecular Biology

CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

R Alemany et al.

GENE THERAPY (2001)

Article Biochemistry & Molecular Biology

Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies

KD Fisher et al.

GENE THERAPY (2001)

Review Genetics & Heredity

Gene therapy -: designer promoters for tumour targeting

DM Nettelbeck et al.

TRENDS IN GENETICS (2000)

Article Virology

Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector

DM Shayakhmetov et al.

JOURNAL OF VIROLOGY (2000)