4.7 Article

Brain-wide versus genome-wide vulnerability biomarkers for severe mental illnesses

Related references

Note: Only part of the references are listed.
Review Neurosciences

ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research

Peter Kochunov et al.

Summary: The ENIGMA-DTI workgroup investigates the effects of psychiatric, neurological, and developmental disorders on white matter pathways in the human brain. They have identified patterns of white matter deficits in various disorders and demonstrated their reproducibility across different cohorts. Applying the regional vulnerability index (RVI) to individual subjects, they have shown the similarity of deficit patterns among different disorders and discussed the differences between idiopathic schizophrenia and 22q11 deletion syndrome. These findings emphasize the importance of collaborative large-scale research in understanding individual vulnerability and cross-diagnosis features.

HUMAN BRAIN MAPPING (2022)

Article Neurosciences

Translating ENIGMA schizophrenia findings using the regional vulnerability index: Association with cognition, symptoms, and disease trajectory

Peter Kochunov et al.

Summary: Patients with schizophrenia exhibit brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white matter integrity. The regional vulnerability index (RVI) can be used to measure these deficits at the individual level. In this study, RVIs were elevated in patients compared to controls, with the multimodal RVI showing the largest effect size. The multimodal and white matter RVIs were elevated in intermediate and chronic patients, suggesting ongoing progression, while cortical RVIs remained stable, indicating neurodevelopmental origins.

HUMAN BRAIN MAPPING (2022)

Article Psychiatry

A White Matter Connection of Schizophrenia and Alzheimer's Disease

Peter Kochunov et al.

Summary: Schizophrenia (SZ) is associated with an elevated risk of developing Alzheimer's disease (AD), both of which have white matter abnormalities and cognitive deficits. The study found that white matter deficit patterns in SZ patients become more similar to those in AD patients with age, with SZ patients showing higher white matter vulnerability compared to healthy controls. Elevated white matter deficits were also associated with cognitive measures in both SZ and AD patients.

SCHIZOPHRENIA BULLETIN (2021)

Review Psychiatry

From Womb to Neighborhood: A Racial Analysis of Social Determinants of Psychosis in the United States

Deidre M. Anglin et al.

Summary: The authors examine the connection between the social environment and outcomes across the psychosis continuum in the U.S., highlighting how structural racism has shaped racial inequities in environmental conditions. They propose a model linking structural racism with psychosis risk through intermediary factors such as neighborhood factors, cumulative trauma and stress, and prenatal and perinatal complications. Evidence shows that Black and Latino people in the U.S. suffer disproportionately from risk factors within these key areas due to racial discrimination and social disadvantage.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

Article Psychiatry

Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis

Qin He et al.

Summary: The study found that cognitive deficits may precede the onset of psychosis. The genetic architecture of schizophrenia seems to impact cognition in UHR-NC individuals, and cognition is also mediated by PRS for resilience.

TRANSLATIONAL PSYCHIATRY (2021)

Article Genetics & Heredity

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Niamh Mullins et al.

Summary: A genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry revealed 64 associated genomic loci, enriched in genes related to synaptic signaling pathways and brain-expressed genes. The study also identified potential therapeutic leads and drug targets, highlighting the complex genetic correlations between bipolar disorder subtypes and providing insights into the disorder's etiology.

NATURE GENETICS (2021)

Article Psychiatry

Multiple dimensions of stress vs. genetic effects on depression

Mark D. Kvarta et al.

Summary: Environmental influence, such as lifetime stressors and current perceived stress, significantly impacts depression, highlighting the importance of considering these factors in genetic studies. In populations with sociocultural homogeneity, stressors play a crucial role in biasing the heritability estimate of depression.

TRANSLATIONAL PSYCHIATRY (2021)

Article Biochemistry & Molecular Biology

Prognostic value of polygenic risk scores for adults with psychosis

Isotta Landi et al.

Summary: Including polygenic risk scores does not enhance the performance of standard-of-care predictive models for disease outcomes in patients with psychosis, according to research analyzing clinical and genetic data from two multi-ethnic cohorts.

NATURE MEDICINE (2021)

Article Psychiatry

The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia

Alexander L. Richards et al.

SCHIZOPHRENIA BULLETIN (2020)

Article Biochemistry & Molecular Biology

White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals

Daisuke Koshiyama et al.

MOLECULAR PSYCHIATRY (2020)

Review Biochemistry & Molecular Biology

y The genetics of bipolar disorder

Francis James A. Gordovez et al.

MOLECULAR PSYCHIATRY (2020)

Editorial Material Biochemistry & Molecular Biology

Unraveling the genetic contributions to complex traits across different ethnic groups

Karen A. Mather et al.

NATURE MEDICINE (2020)

Editorial Material Psychiatry

Toward High Reproducibility and Accountable Heterogeneity in Schizophrenia Research

Peter Kochunov et al.

JAMA PSYCHIATRY (2019)

Article Psychiatry

White Matter in Schizophrenia Treatment Resistance

Peter Kochunov et al.

AMERICAN JOURNAL OF PSYCHIATRY (2019)

Article Biochemistry & Molecular Biology

A direct test of the diathesis-stress model for depression

L. Colodro-Conde et al.

MOLECULAR PSYCHIATRY (2018)

Review Genetics & Heredity

The personal and clinical utility of polygenic risk scores

Ali Torkamani et al.

NATURE REVIEWS GENETICS (2018)

Article Psychiatry

Association Between Population Density and Genetic Risk for Schizophrenia

Lucia Colodro-Conde et al.

JAMA PSYCHIATRY (2018)

Article Psychiatry

Genetic correlates of insight in schizophrenia

Rose Mary Xavier et al.

SCHIZOPHRENIA RESEARCH (2018)

Article Multidisciplinary Sciences

The UK Biobank resource with deep phenotyping and genomic data

Clare Bycroft et al.

NATURE (2018)

Review Psychology, Clinical

Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective

Julia M. Sheffield et al.

NEUROPSYCHOLOGY REVIEW (2018)

Article Public, Environmental & Occupational Health

Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population

Anna Fry et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2017)

Article Biochemistry & Molecular Biology

Abnormal asymmetries in subcortical brain volume in schizophrenia

N. Okada et al.

MOLECULAR PSYCHIATRY (2016)

Review Genetics & Heredity

Developing and evaluating polygenic risk prediction models for stratified disease prevention

Nilanjan Chatterjee et al.

NATURE REVIEWS GENETICS (2016)

Article Psychiatry

Polygenic Risk of Schizophrenia and Cognition in a Population-Based Survey of Older Adults

David T. Liebers et al.

SCHIZOPHRENIA BULLETIN (2016)

Review Pediatrics

Assessing childhood maltreatment on the population level in Germany: findings and methodological challenges

Heide Glaesmer

CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH (2016)

Review Clinical Neurology

Cognitive markers of psychotic unipolar depression: A meta-analytic study

Leonardo Zaninotto et al.

JOURNAL OF AFFECTIVE DISORDERS (2015)

Review Biochemistry & Molecular Biology

Evaluating historical candidate genes for schizophrenia

M. S. Farrell et al.

MOLECULAR PSYCHIATRY (2015)

Article Multidisciplinary Sciences

Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke et al.

NATURE (2014)

Article Psychiatry

Cognitive impairments in psychotic disorders: common mechanisms and measurement

Deanna M. Barch et al.

WORLD PSYCHIATRY (2014)

Editorial Material Medicine, General & Internal

How to Make More Published Research True

John P. A. Ioannidis

PLOS MEDICINE (2014)

Article Genetics & Heredity

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

S. Hong Lee et al.

NATURE GENETICS (2013)

Editorial Material Public, Environmental & Occupational Health

New Models for Large Prospective Studies: Is There a Better Way?

Teri A. Manolio et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2012)

Article Psychiatry

Cognitive Functioning in Prodromal Psychosis A Meta-analysis

Paolo Fusar-Poli et al.

ARCHIVES OF GENERAL PSYCHIATRY (2012)

Article Biochemistry & Molecular Biology

Poor replication of candidate genes for major depressive disorder using genome-wide association data

F. J. Bosker et al.

MOLECULAR PSYCHIATRY (2011)

Article Psychiatry

Processing Speed Deficits in Schizophrenia: Reexamining the Evidence

Emma E. M. Knowles et al.

AMERICAN JOURNAL OF PSYCHIATRY (2010)

Article Neurosciences

Cortical Thickness and Subcortical Volumes in Schizophrenia and Bipolar Disorder

Lars M. Rimol et al.

BIOLOGICAL PSYCHIATRY (2010)

Article Multidisciplinary Sciences

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Shaun M. Purcell et al.

NATURE (2009)

Review Neurosciences

THE GENETICS OF BIPOLAR DISORDER

J. H. Barnett et al.

NEUROSCIENCE (2009)

Article Neurosciences

White Matter Tractography in Bipolar Disorder and Schizophrenia

Andrew M. McIntosh et al.

BIOLOGICAL PSYCHIATRY (2008)

Article Neurosciences

Retrospective motion correction protocol for high-resolution anatomical MRI

Peter Kochunov et al.

HUMAN BRAIN MAPPING (2006)

Article Neurosciences

Defining a cognitive function decrement in schizophrenia

RSE Keefe et al.

BIOLOGICAL PSYCHIATRY (2005)

Article Genetics & Heredity

Family, twin, and adoption studies of bipolar disorder

JW Smoller et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS (2003)