Journal
GENESIS
Volume 60, Issue 8-9, Pages -Publisher
WILEY
DOI: 10.1002/dvg.23498
Keywords
calvarial bone; dental apparatus; intravital imaging; skeletal stem cells
Categories
Funding
- Bone Disease Program of Texas Award
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01AR072018, R61AR078073, T32DK060445]
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This article reviews the applications of noninvasive intravital imaging techniques in the study of stem/progenitor cells in the craniofacial and dental apparatus, as well as the limitations and challenges in providing real-time insights into bone stem cell dynamics and function.
Craniofacial and appendicular bone homeostasis is dynamically regulated by a balance between bone formation and resorption by osteoblasts and osteoclasts, respectively. Despite the developments in multiple imaging techniques in bone biology, there are still technical challenges and limitations in the investigation of spatial/anatomical location of rare stem/progenitor cells and their molecular regulation in tooth and craniofacial bones of living animals. Recent advances in live animal imaging techniques for the craniofacial and dental apparatus can provide new insights in real time into bone stem/progenitor cell dynamics and function in vivo. Here, we review the current inventions and applications of the noninvasive intravital imaging technique and its practical uses and limitations in the analysis of stem/progenitor cells in craniofacial and dental apparatus in vivo. Furthermore, we also explore the potential applications of intravital microscopy in the dental field.
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