Journal
FUTURE MICROBIOLOGY
Volume 17, Issue 13, Pages 1071-1089Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2021-0072
Keywords
colorectal cancer; gut micro-organisms; immune cell; intestinal inflammation; intestinal microecology; microbial-associated molecular patterns; pattern recognition receptors; probiotics; toll-like receptors
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Funding
- Advanced Soldier Program of Science and Technology Department of Zhejiang Province [2022C03026]
- Major Science and Technology Projects of Zhejiang Provincial Health Commission [WKJ-ZJ-2013]
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This study suggests that the occurrence of colorectal cancer is closely related to gut micro-organisms, and the micro-organisms can promote or inhibit the development of colorectal cancer by binding to toll-like receptors. This finding has important implications for future tumor immunotherapy and targeted therapy.
Colorectal cancer (CRC) is one of the most considerably common malignancies of the alimentary system, with high mortality and incidence rates. The present study suggested that the occurrence of CRC is closely related to bacteria, as the large intestine is a gathering place for human micro-organisms. However, the nosogenesis of bacteria leading to tumorigenesis is still obscure. Recently, many studies have reported that toll-like receptors and their related molecular pathways are involved in the process of gut micro-organisms generating CRC. Gut micro-organisms can promote or inhibit the development of CRC via binding to special toll-like receptors. In this paper, the authors review the relationship among toll-like receptors, gut micro-organisms and CRC in order to provide a reference for future tumor immunotherapy and targeted therapy.
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