Journal
FUTURE MEDICINAL CHEMISTRY
Volume 14, Issue 21, Pages 1583-1606Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2022-0170
Keywords
Alzheimer's disease; multicomponent reactions; multitarget-directed ligand strategy
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Funding
- Regional Council of Bourgogne Franche Comte'ocial, and governance disclosure: Any difference between financial and non-financial companies? [2022Y-13659, 2022Y-13660]
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Alzheimer's disease is a common neurodegenerative disease in the older population, and the use of multitarget-directed ligand strategy can lead to the development of complex molecules with multiple pharmacophores as a treatment approach.
Among neurodegenerative pathologies affecting the older population, Alzheimer's disease is the most common type of dementia and leads to neurocognitive and behavioral disorders. It is a complex and progressive age-related multifactorial disease characterized by a series of highly interconnected pathophysiological processes. Within the last decade, the multitarget-directed ligand strategy has emerged as a viable approach to developing complex molecules that exhibit several pharmacophores which can target the different enzymes and receptors involved in the pathogenesis of the disease. Herein, we focus on using multicomponent reactions such as Hantzsch, Biginelli and Ugi to develop these biologically active multitopic ligands.
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