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JOURNAL OF ALZHEIMERS DISEASE (2017)
Cerebral Hypoperfusion and Glucose Hypometabolism: Key Pathophysiological Modulators Promote Neurodegeneration, Cognitive Impairment, and Alzheimer's Disease
Mak Adam Daulatzai
JOURNAL OF NEUROSCIENCE RESEARCH (2017)
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease
Giuseppe Arena et al.
JOURNAL OF PATHOLOGY (2017)
Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease
Ralph A. Nixon
FASEB JOURNAL (2017)
Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer's Disease
Joao A. Amorim et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease
Eric Tonnies et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Mitochondrial Dysfunction Triggers Synaptic Deficits via Activation of p38 MAP Kinase Signaling in Differentiated Alzheimer's Disease Trans-Mitochondrial Cybrid Cells
Qing Yu et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons
Han-Kyu Lee et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease
Qian Cai et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin
Bin Xiao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
2,3-Dihydro-3β-methoxy Withaferin-A Protects Normal Cells against Stress: Molecular Evidence of Its Potent Cytoprotective Activity
Anupama Chaudhary et al.
JOURNAL OF NATURAL PRODUCTS (2017)
Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?
A. Knezovic et al.
JOURNAL OF NEURAL TRANSMISSION (2017)
Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain
Nona Abolhassani et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2017)
CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis
Renu Wadhwa et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2017)
Hexokinases link DJ-1 to the PINK1/parkin pathway
David N. Hauser et al.
MOLECULAR NEURODEGENERATION (2017)
The blood-brain barrier in Alzheimer's disease
Elena Zenaro et al.
NEUROBIOLOGY OF DISEASE (2017)
Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
Na Zhao et al.
NEURON (2017)
Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms
Jesse S. Kerr et al.
TRENDS IN NEUROSCIENCES (2017)
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
Weikang Cai et al.
NATURE COMMUNICATIONS (2017)
Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD
Masayoshi Takeuchi et al.
NUTRIENTS (2017)
A novel Alzheimer's disease drug candidate targeting inflammation and fatty acid metabolism
Daniel Daugherty et al.
ALZHEIMERS RESEARCH & THERAPY (2017)
Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer's Disease
Roger J. Mullins et al.
FRONTIERS IN AGING NEUROSCIENCE (2017)
Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages
Bryan J. Neth et al.
FRONTIERS IN AGING NEUROSCIENCE (2017)
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease
Altea Rocchi et al.
PLOS GENETICS (2017)
AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity
Josien Levenga et al.
ELIFE (2017)
Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
E. Lauretti et al.
TRANSLATIONAL PSYCHIATRY (2017)
Nanoparticles as potential clinical therapeutic agents in Alzheimer's disease: focus on selenium nanoparticles
Mustafa Naziroglu et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2017)
Cerebral Gluconeogenesis and Diseases
James Yip et al.
FRONTIERS IN PHARMACOLOGY (2017)
Protocatechuic Acid, a Phenolic from Sansevieria roxburghiana Leaves, Suppresses Diabetic Cardiomyopathy via Stimulating Glucose Metabolism, Ameliorating Oxidative Stress, and Inhibiting Inflammation
Niloy Bhattacharjee et al.
FRONTIERS IN PHARMACOLOGY (2017)
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease
Minna Oksanen et al.
STEM CELL REPORTS (2017)
Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages
Weishan Fang et al.
SCIENTIFIC REPORTS (2017)
Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases
Alejandro Gugliucci
ADVANCES IN NUTRITION (2017)
Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats
Ritu Khanra et al.
BIOMEDICINE & PHARMACOTHERAPY (2017)
S-Adenosylmethionine and Superoxide Dismutase 1 Synergistically Counteract Alzheimer's Disease Features Progression in TgCRND8 Mice
Rosaria A. Cavallaro et al.
ANTIOXIDANTS (2017)
Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease
Marta Pera et al.
EMBO JOURNAL (2017)
Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/RNS generation
Waqar Ahmad et al.
JOURNAL OF BIOMEDICAL SCIENCE (2017)
Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
Grazia R. Tundo et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)
Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies
Jasvinder Singh Bhatti et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)
Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal
Ramesh Kandimalla et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)
High fat diet induces brain insulin resistance and cognitive impairment in mice
Vishal Kothari et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)
Physical Activity: A Viable Way to Reduce the Risks of Mild Cognitive Impairment, Alzheimer's Disease, and Vascular Dementia in Older Adults
Patrick J. Gallaway et al.
BRAIN SCIENCES (2017)
Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer's disease
Amandine Grimm et al.
BIOGERONTOLOGY (2016)
Uremic Toxicity of Advanced Glycation End Products in CKD
Andrea E. M. Stinghen et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)
Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?
Olga Pivovarova et al.
ANNALS OF MEDICINE (2016)
Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis
Ramesh Kandimalla et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)
Glucose Metabolism: A Sweet Relief of Alzheimer's Disease
Claudia Duran-Aniotz et al.
CURRENT BIOLOGY (2016)
The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders
Gerwyn Morris et al.
CURRENT PHARMACEUTICAL DESIGN (2016)
The amyloid hypothesis of Alzheimer's disease at 25years
Dennis J. Selkoe et al.
EMBO MOLECULAR MEDICINE (2016)
Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: An update
Niloy Bhattacharjee et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2016)
Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm
Eugenio Barone et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
The Dynamics and Turnover of Tau Aggregates in Cultured Cells INSIGHTS INTO THERAPIES FOR TAUOPATHIES
Jing L. Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Peptidyl-Proline Isomerases (PPlases): Targets for Natural Products and Natural Product-Inspired Compounds
Bryan M. Dunyak et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons
Raffaella Mastrocola et al.
NEUROBIOLOGY OF DISEASE (2016)
THE ROLE OF INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) IN BRAIN DEVELOPMENT, MATURATION AND NEUROPLASTICITY
Adam H. Dyer et al.
NEUROSCIENCE (2016)
Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aβ-Mediated Mitochondrial Dysfunction
Koteswara Rao Valasani et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease
Simon J. Beck et al.
NATURE COMMUNICATIONS (2016)
Therapies for Prevention and Treatment of Alzheimer's Disease
J. Mendiola-Precoma et al.
BIOMED RESEARCH INTERNATIONAL (2016)
5 '-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications
Fan Yao et al.
ACTA PHARMACEUTICA SINICA B (2016)
Autophagic and lysosomal defects in human tauopathies: analysis of postmortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
Antonio Piras et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)
Regulation and function of AMPK in physiology and diseases
Sang-Min Jeon
EXPERIMENTAL AND MOLECULAR MEDICINE (2016)
Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients
Scott Maynard et al.
AGING-US (2015)
Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi
Per Nilsson et al.
AMERICAN JOURNAL OF PATHOLOGY (2015)
Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in insulin insensitivity of mammalian cells
Chih-Hao Wang et al.
MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE (2015)
Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update
Zhi-Gang Zhang et al.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2015)
Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers
Cristina Carvalho et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)
Extracellular ATP modulates synaptic plasticity induced by activation of metabotropic glutamate receptors in the hippocampus
Yoshihiko YAMAZAKI et al.
BIOMEDICAL RESEARCH-TOKYO (2015)
Neurobiology of Alzheimer's Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions
Joel Raskin et al.
CURRENT ALZHEIMER RESEARCH (2015)
Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity
Wen Fu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance
Geraldine Gontier et al.
JOURNAL OF NEUROSCIENCE (2015)
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Michael Lazarou et al.
NATURE (2015)
Innate immunity in Alzheimer's disease
Michael T. Heneka et al.
NATURE IMMUNOLOGY (2015)
Sugar and Alzheimer's disease: a bittersweet truth
Costantino Iadecola
NATURE NEUROSCIENCE (2015)
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
Ethan A. Winkler et al.
NATURE NEUROSCIENCE (2015)
Immune attack: the role of inflammation in Alzheimer disease
Frank L. Heppner et al.
NATURE REVIEWS NEUROSCIENCE (2015)
Abnormal Glucose Metabolism in Alzheimer's Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches
Kalpita Banerjee et al.
NEUROCHEMICAL RESEARCH (2015)
Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation
Maja Jazvinscak Jembrek et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
Andre Kleinridders et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape
Antero Salminen et al.
PROGRESS IN NEUROBIOLOGY (2015)
PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402
Liesbeth Aerts et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide
Bret D. Freudenthal et al.
NATURE (2015)
Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation
Navjot Shah et al.
PLOS ONE (2015)
Endoplasmic Reticulum Stress Impairs Insulin Receptor Signaling in the Brains of Obese Rats
Lina Liang et al.
PLOS ONE (2015)
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies
Mark Yarchoan et al.
ACTA NEUROPATHOLOGICA (2014)
At the Centennial of Michaelis and Menten, Competing Michaelis-Menten Steps Explain Effect of GLP-1 on Blood-Brain Transfer and Metabolism of Glucose
Michael Gejl et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)
NDP52 associates with phosphorylated tau in brains of an Alzheimer disease mouse model
Sunhyo Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
March separate, strike together - Role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease
Anne Eckert et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Oxidative stress and mitochondrial dysfunction in Alzheimer's disease
Xinglong Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Mitochondrial permeability transition pore is a potential drug target for neurodegeneration
Valasani Koteswara Rao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
Evandro Fei Fang et al.
CELL (2014)
Regulation of pyruvate metabolism and human disease
Lawrence R. Gray et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
David Heras-Sandoval et al.
CELLULAR SIGNALLING (2014)
Insulin Reverses the High-Fat Diet-Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease
Milene Vandal et al.
DIABETES (2014)
Alterations in White Matter Structure in Young Children With Type 1 Diabetes
Naama Barnea-Goraly et al.
DIABETES CARE (2014)
RNA-Seq Data Mining: Downregulation of NeuroD6 Serves as a Possible Biomarker for Alzheimer's Disease Brains
Jun-ichi Satoh et al.
DISEASE MARKERS (2014)
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
Vinicia A. Polito et al.
EMBO MOLECULAR MEDICINE (2014)
Hexokinase activity is required for recruitment of parkin to depolarized mitochondria
Melissa K. McCoy et al.
HUMAN MOLECULAR GENETICS (2014)
Expression of the Glucose Transporter GLUT12 in Alzheimer's Disease Patients
Jonai Pujol-Gimenez et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation
Nancy J. Hancer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
Lesley A. Kane et al.
JOURNAL OF CELL BIOLOGY (2014)
GABAergic Neurogliaform Cells Represent Local Sources of Insulin in the Cerebral Cortex
Gabor Molnar et al.
JOURNAL OF NEUROSCIENCE (2014)
Ubiquitin is phosphorylated by PINK1 to activate parkin
Fumika Koyano et al.
NATURE (2014)
AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons
G. Amadoro et al.
NEUROBIOLOGY OF DISEASE (2014)
Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD
Lisa Mosconi et al.
NEUROLOGY (2014)
Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin
Melita Salkovic-Petrisic et al.
NEUROPHARMACOLOGY (2014)
Mitochondrial Dysfunction: Different Routes to Alzheimer's Disease Therapy
Pasquale Picone et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)
Truncated and modified amyloid-beta species
Markus P. Kummer et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway
Peizhou Jiang et al.
FRONTIERS IN AGING NEUROSCIENCE (2014)
Insulin as a bridge between type 2 diabetes and Alzheimer disease - how anti-diabetics could be a solution for dementia
Ines Sebastiao et al.
FRONTIERS IN ENDOCRINOLOGY (2014)
Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease
Oliver Stoehr et al.
AGE (2013)
Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity
Maria P. Guarino et al.
AGE (2013)
mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
Antonella Caccamo et al.
AGING CELL (2013)
Mitochondrial Pathways, Permeability Transition Pore, and Redox Signaling in Cardioprotection: Therapeutic Implications
Claudia Penna et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis
Krishnendu Sinha et al.
ARCHIVES OF TOXICOLOGY (2013)
TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer's β-Amyloid Oligomers in Mice and Monkeys
Mychael V. Lourenco et al.
CELL METABOLISM (2013)
Animal Models of the Sporadic Form of Alzheimer's Disease: Focus on the Disease and Not Just the Lesions
Khalid Iqbal et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
William A. Eimer et al.
MOLECULAR NEURODEGENERATION (2013)
Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer's Neurons
Lan Guo et al.
PLOS ONE (2013)
Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies
Zhichun Chen et al.
PROGRESS IN NEUROBIOLOGY (2013)
Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation
Jean-Francois Trempe et al.
SCIENCE (2013)
Sugar for the brain: the role of glucose in physiological and pathological brain function
Philipp Mergenthaler et al.
TRENDS IN NEUROSCIENCES (2013)
Enhanced levels of double-strand DNA break repair proteins protect ovarian cancer cells against genotoxic stress-induced apoptosis
Rajkumar Singh Kalra et al.
JOURNAL OF OVARIAN RESEARCH (2013)
Aβ Secretion and Plaque Formation Depend on Autophagy
Per Nilsson et al.
CELL REPORTS (2013)
Initial stages of beta-amyloid Aβ1-40 and Aβ1-42 oligomerization observed using fluorescence decay and molecular dynamics analyses of tyrosine
Mariana Amaro et al.
METHODS AND APPLICATIONS IN FLUORESCENCE (2013)
Glucose metabolism in normal aging and Alzheimer's disease: methodological and physiological considerations for PET studies
Lisa Mosconi
CLINICAL AND TRANSLATIONAL IMAGING (2013)
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus
Raquel Sanchez-Varo et al.
ACTA NEUROPATHOLOGICA (2012)
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
Antero Salminen et al.
AGEING RESEARCH REVIEWS (2012)
Strategic Role for Mitochondria in Alzheimer's Disease and Cancer
Louise Hedskog et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation
Kristina Leuner et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy
Veronique Schaeffer et al.
AUTOPHAGY (2012)
Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation
Sonia C. Correia et al.
BRAIN RESEARCH (2012)
Interleukin-1 (IL-1) family of cytokines: Role in Type 2 Diabetes
Monisha Banerjee et al.
CLINICA CHIMICA ACTA (2012)
Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease
Suzanne M. de la Monte
Current Alzheimer Research (2012)
Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders
Mithilesh Kumar Jha et al.
Current Neuropharmacology (2012)
Inflammation and type 2 diabetes
M. C. Calle et al.
DIABETES & METABOLISM (2012)
Neuronal autophagy and neurodegenerative diseases
Jin H. Son et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2012)
The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer's Disease
Kaushik Shah et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
The impairment of insulin signaling in Alzheimer's disease
Emanuel Candeias et al.
IUBMB LIFE (2012)
Impaired Neuronal Insulin Signaling Precedes Aβ42 Accumulation in Female AβPPsw/PS1ΔE9 Mice
Li-Min Chua et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
Konrad Talbot et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Cognitive reserve in ageing and Alzheimer's disease
Yaakov Stern
LANCET NEUROLOGY (2012)
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
Keiichi Inoue et al.
MOLECULAR NEURODEGENERATION (2012)
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
Scott A. Yuzwa et al.
NATURE CHEMICAL BIOLOGY (2012)
Interaction between NH2-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration
Giuseppina Amadoro et al.
NEUROBIOLOGY OF AGING (2012)
Roles of AMP-activated Protein Kinase in Alzheimer's Disease
Zhiyou Cai et al.
NEUROMOLECULAR MEDICINE (2012)
Chronic peripheral hyperinsulinemia has no substantial influence on tau phosphorylation in vivo
Katrin Becker et al.
NEUROSCIENCE LETTERS (2012)
Mitochondrial Fission, Fusion, and Stress
Richard J. Youle et al.
SCIENCE (2012)
Insulin resistance in the nervous system
Bhumsoo Kim et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Chandana Kondapalli et al.
OPEN BIOLOGY (2012)
Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons
Marcus J. Calkins et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2011)
Effects of Hypoperfusion in Alzheimer's Disease
Benjamin P. Austin et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Decreased Proteolytic Activity of the Mitochondrial Amyloid-beta Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria
Nyosha Alikhani et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model
Sebastian Jimenez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis
Domenico Bosco et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)
Mitochondrial dysfunction in patients with primary congenital insulin resistance
Alison Sleigh et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
Ying Liu et al.
JOURNAL OF PATHOLOGY (2011)
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
Berislav V. Zlokovic
NATURE REVIEWS NEUROSCIENCE (2011)
Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model
Heng Du et al.
NEUROBIOLOGY OF AGING (2011)
Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
Smita Majumder et al.
PLOS ONE (2011)
Basal Insulin: Beyond Glycemia
Kevin D. Niswender
POSTGRADUATE MEDICINE (2011)
Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
Loredana Stoica et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Parallel findings in age-related macular degeneration and Alzheimer's disease
Kyoko Ohno-Matsui
PROGRESS IN RETINAL AND EYE RESEARCH (2011)
Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence
Jia Yao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)
Irs1 Serine 307 Promotes Insulin Sensitivity in Mice
Kyle D. Copps et al.
CELL METABOLISM (2010)
A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments
Gary E. Gibson et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Quantitative Changes in the Mitochondrial Proteome from Subjects with Mild Cognitive Impairment, Early Stage, and Late Stage Alzheimer's Disease
Bert C. Lynn et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau EFFECTS ON COGNITIVE IMPAIRMENTS
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex
Mubeen A. Ansari et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)
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S Craft
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S Tacconi et al.
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