4.7 Review

Advances in analysis, metabolism and mimicking of human milk lipids

Journal

FOOD CHEMISTRY
Volume 393, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2022.133332

Keywords

Human milk lipids; Profiling lipids; Digestion and absorption; Biological activity; Mimicking

Funding

  1. National Key RAMP
  2. D Program of China [2019YFF0216702]
  3. Guangxi Science and Technology project [AD20297088]
  4. National Natural Science Foundation of China [32072191]
  5. Na-tional Key RAMP
  6. D Program of China [2018YFC1604301-03]

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The differences in composition and distribution of fatty acids make human milk lipids distinct from those of other mammals. Understanding the concentrations, compositions, and distribution characteristics of milk lipids requires analysis and detection technology. The characteristics and mimicking of human milk lipids have been extensively studied to reduce the gap between human milk and infant formulae.
Human milk lipids differ from the milk lipids of other mammals in composition and positional distribution of fatty acids. Analysis and detection technology of lipids is key to understanding milk lipids, and thus the concentrations, compositions and distribution characteristics of milk lipids are discussed. Differences between human milk lipids and their substitutes in form, composition and structure affect their digestion, absorption and function in infants. Characteristics and mimicking of human milk lipids have been intensively studied with the objective of narrowing the gap between human milk and infant formulae. Based on the existing achievements, further progress may be made by improving detection techniques, deepening knowledge of metabolic pathways and perfecting fat substitutes. This review detailed the characteristics of human milk lipids and related detection technologies with a view towards providing a clear direction for research on mimicking human milk lipids in formulae to further improve infant nutrition.

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