Journal
EYE
Volume 37, Issue 9, Pages 1766-1773Publisher
SPRINGERNATURE
DOI: 10.1038/s41433-022-02270-5
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This review examines the literature on choroidal thickness and choroidal vascularity index in patients with RP, and evaluates whether these markers reflect the progression of the disease from an anatomical and functional perspective.
Retinitis pigmentosa (RP) is the commonest inherited retinal dystrophy. It is characterized by progressive photoreceptor degeneration and cell death and ongoing neuronal and vascular impairment. In recent years, pathophysiological alterations of the choroid have begun to be appreciated in RP. Thus, representing a potential diagnostic and therapeutic biomarker. In particular, choroidal thickness and the choroidal vascularity index can be used to understand the pathogenesis of disease and evaluate new therapeutic possibilities. Photoreceptor changes seen in eyes with RP are directly correlated to a decrease of choroidal flow, leading to a strong association between relative choroidal ischemia and visual impairment. In this review we analyse the literature on choroidal thickness and choroidal vascularity index in patients with RP and assess whether these markers may reflect progression of disease from an anatomical and functional point of view.
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