Long non-coding RNAs (lncRNAs); roles in tumorigenesis and potentials as biomarkers in cancer diagnosis

New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a broad range of bio-logical processes, including the pathogenesis of many complex human diseases, including cancer. The detailed regulation mechanisms of many lncRNAs in cancer initiation and progression have yet to be discovered, even though a few of lncRNAs' functions in cancer have been characterized. In the present study, we summarize recent advances in the mechanisms and functions of lncRNAs in cancer. We focused on the roles of newly-identified lncRNAs as oncogenes and tumor suppressors, as well as the potential pathways these molecules could play. The paper also discusses their potential uses as biomarkers for the diagnosis and prognosis of cancer.

Automated summary

New research has shown that long non-coding RNAs (lncRNAs) play crucial roles in various biological processes, including the development of complex human diseases like cancer. Although the specific regulation mechanisms of many lncRNAs in cancer are still unknown, a few have been identified. This study provides a summary of recent advances in understanding the mechanisms and functions of lncRNAs in cancer, with a focus on their roles as oncogenes and tumor suppressors, as well as their potential use as biomarkers for cancer diagnosis and prognosis.