Age-specific associations between underlying health conditions and hospitalisation, death and in-hospital death among confirmed COVID-19 cases: a multi-country study based on surveillance data, June to December 2020

Article Immunology

Risk Factors for Intensive Care Unit Admission and In-hospital Mortality Among Hospitalized Adults Identified through the US Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET)

Lindsay Kim et al.

Summary: This study identified factors associated with severe outcomes among adults hospitalized with COVID-19, including age, sex, comorbidities like obesity, immunosuppression, and diabetes. Older age, male gender, and certain underlying conditions were independently linked to increased risk of ICU admission and in-hospital mortality.

CLINICAL INFECTIOUS DISEASES (2021)

Add to Collection

Review Virology

The effect of smoking on COVID-19 severity: A systematic review and meta-analysis

Rohin K. Reddy et al.

Summary: Smoking is associated with increased risk of severe COVID-19 and worse in-hospital outcomes, as current smokers and patients with a smoking history are more susceptible to severe disease and have higher mortality rates.

JOURNAL OF MEDICAL VIROLOGY (2021)

Add to Collection

Article Immunology

Risk Factors for Severe COVID-19 in Children

Kelly Graff et al.

Summary: This study found that extremes of age, comorbid conditions, and elevated CRP are predictors of severe COVID-19 disease in children. These findings can help pediatric providers and public health officials tailor clinical management and resource allocation strategies more effectively.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2021)

Add to Collection

Article Public, Environmental & Occupational Health

Sex-Based Differences in COVID-19 Outcomes

Astha Tejpal et al.

Summary: The study found that female sex is associated with lower odds of in-hospital mortality, major adverse events, and all-cause mortality in patients hospitalized with COVID-19. This suggests that there may be inherent protective mechanisms specific to female sex.

JOURNAL OF WOMENS HEALTH (2021)

Add to Collection

Review Multidisciplinary Sciences

Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis

Xinyang Li et al.

Summary: The study identified potential risk factors for severe COVID-19 cases, including advanced age, male gender, obesity, smoking history, hypertension, diabetes, coronary heart disease, chronic kidney disease, cerebrovascular disease, chronic obstructive pulmonary disease, malignancy, and chronic liver disease. Acute respiratory distress syndrome, shock, and acute kidney injury were found to be major hindrances to recovery.

PLOS ONE (2021)

Add to Collection

Review Multidisciplinary Sciences

A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic

Hyung-Jun Kim et al.

Summary: The mortality rates of COVID-19 vary globally, with different risk factors influencing critical outcomes such as sex, age, underlying medical conditions, symptoms, and laboratory findings. Regional studies suggest differences in the impact of respiratory and hepatic diseases, symptoms, and blood test results on critical outcomes between Asia, Europe, and North America.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Medicine, General & Internal

Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

Lyudmyla Kompaniyets et al.

Summary: This study investigated the risk of severe COVID-19 illness among children with underlying medical conditions and medical complexity. It found that children with type 1 diabetes, cardiac and circulatory congenital anomalies, and obesity had a higher risk of severe COVID-19 illness, highlighting the importance of close observation and cautious clinical management for these children.

JAMA NETWORK OPEN (2021)

Add to Collection

Review Medicine, General & Internal