☆ 4.7 Article

Non-coding RNAs in EMT regulation: Association with tumor progression and therapy response

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Cancer-associated fibroblast-derived exosomal miR-18b promotes breast cancer invasion and metastasis by regulating TCEAL7

Ziqian Yan et al.

Summary: Studies compared the effects of CAFs-derived exosomes and NFs-derived exosomes on breast cancer cells, finding that CAFs-derived exosomes had a stronger enhancing effect on migration and invasion.

CELL DEATH & DISEASE (2021)

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Article Oncology

Hsa-circ_0058106 induces EMT and metastasis in laryngeal cancer via sponging miR-153 and inducing Twist1 nuclear translocation

Xiaowen Zhang et al.

Summary: The newly discovered circular RNA hsa-circ_0058106 is upregulated in laryngeal cancer and is associated with lymph node metastasis and advanced clinical stages. Silencing hsa-circ_0058106 inhibits migration and invasion of laryngeal cancer cells, and suppresses epithelial-mesenchymal transition (EMT). Mechanistically, hsa-circ_0058106 sponges miR-153 to regulate Snail1 expression and blocks the nuclear translocation of Twist1.

CELLULAR ONCOLOGY (2021)

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Article Reproductive Biology

MiR-149-3p promotes the cisplatin resistance and EMT in ovarian cancer through downregulating TIMP2 and CDKN1A

Jin Wang et al.

Summary: miR-149-3p is highly expressed in ovarian cancer tissues and associated with poor survival. It promotes cisplatin resistance and epithelial-mesenchymal transition in OC, potentially serving as a therapeutic target for OC treatment.

JOURNAL OF OVARIAN RESEARCH (2021)

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Article Cell Biology

Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling

Jian Bai et al.

Summary: The study revealed that miR-128-3p regulates EMT between CRC cells through exosomal delivery by directly suppressing FOXO4 to activate TGF-beta/SMAD and JAK/STAT3 signaling pathways. High expression of miR-128-3p was significantly associated with pathological features in CRC patients, suggesting that exosomal miR-128-3p could serve as a novel therapeutic approach for CRC.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Targeting a novel LncRNA SNHG15/miR-451/c-Myc signaling cascade is effective to hamper the pathogenesis of breast cancer (BC) in vitro and in vivo

Jiang Du et al.

Summary: The study revealed that LncRNA SNHG15 upregulated c-Myc by sponging miR-451 in a ceRNA-dependent manner to promote breast cancer progression. The expressions of LncRNA SNHG15 and c-Myc were elevated, while miR-451 was decreased in BC cells and tissues. MiR-451 negatively correlated with LncRNA SNHG15 and c-Myc, while LncRNA SNHG15 positively correlated with c-Myc in BC tissues.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

Circular RNA hsa_circ_0003288 induces EMT and invasion by regulating hsa_circ_0003288/miR-145/PD-L1 axis in hepatocellular carcinoma

Guili Xu et al.

Summary: This study demonstrated that hsa_circ_0003288 promotes EMT and invasion of HCC through the hsa_circ_0003288/miR-145/PD-L1 axis via the PI3K/Akt pathway. Targeting hsa_circ_0003288 may be a therapeutic strategy for the treatment of HCC.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma

Shuwei Chen et al.

Summary: The study revealed that FOXD1 is upregulated in oral squamous cell cancer (OSCC) and promotes chemoresistance and epithelial-mesenchymal transition (EMT), with the CYTOR/LPP axis playing a key role in this process. FOXD1 may serve as a potential prognostic marker and therapeutic target for overcoming chemotherapy resistance in OSCC.

CANCER LETTERS (2021)

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Article Genetics & Heredity

Circ_0092367 Inhibits EMT and Gemcitabine Resistance in Pancreatic Cancer via Regulating the miR-1206/ESRP1 Axis

Shuo Yu et al.

Summary: The study demonstrated that circ_0092367 plays a crucial role in sensitizing pancreatic cancer cells to gemcitabine by inhibiting epithelial-mesenchymal transition and enhancing treatment sensitivity. High expression of circ_0092367 was associated with improved survival in pancreatic cancer patients, suggesting its potential as a valuable therapeutic target.

GENES (2021)

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Article Biotechnology & Applied Microbiology

Exosomal miR-4488 and miR-1273g-5p inhibit the epithelial-mesenchymal transition of transforming growth factor β2-mediated retinal pigment epithelial cells by targeting ATP-binding cassette A4

Hongtao Dong et al.

Summary: Our findings demonstrate that exosomal miR-4488 and miR-1273 g-5p can inhibit TGF-beta 2-induced EMT in ARPE-19 cells by targeting ABCA4. Overexpression of these miRNAs suppresses migration and invasion, while promoting apoptosis in the TGF-beta 2-induced ARPE-19 cells. ABCA4 serves as a target for miR-4488 and miR-1273 g-5p, and overexpressing ABCA4 can reverse the negative regulation of the exosomal miRNAs on EMT, migration, and invasion in these cells.

BIOENGINEERED (2021)

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Article Biotechnology & Applied Microbiology

LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/β-catenin pathway

Yanli Guo et al.

Summary: The research highlights the critical role of DDX11-AS1 in ESCC, demonstrating its involvement in promoting ESCC progression by regulating the expression of miR-30d-5p and SNAI1/ZEB2, as well as activating the Wnt/beta-catenin pathway.

BIOENGINEERED (2021)

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Article Oncology

LncRNA PAINT is associated with aggressive prostate cancer and dysregulation of cancer hallmark genes

Md Faqrul Hasan et al.

Summary: The long noncoding RNA PAINT plays a promotive role in prostate cancer progression, with its inhibition reducing cell proliferation and migration while improving drug sensitivity. This study establishes a novel oncogenic function of PAINT in prostate cancer, providing new insights for potential therapeutic strategies.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Oncology

miR-125b Promotes Colorectal Cancer Migration and Invasion by Dual-Targeting CFTR and CGN

Xiaohui Zhang et al.

Summary: In this study, we identified a novel mechanism by which miR-125b enhances metastasis in CRC by targeting CFTR and CGN, promoting EMT and uPA expression and secretion, and enhancing RhoA/ROCK signaling pathway. These findings suggest miR-125b as a key functional molecule in CRC and a promising biomarker for the diagnosis and treatment of CRC.

CANCERS (2021)

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Article Oncology

LncRNA LGALS8-AS1 Promotes Breast Cancer Metastasis Through miR-125b-5p/SOX12 Feedback Regulatory Network

Duanyang Zhai et al.

Summary: This study identified that the lncRNA LGALS8-AS1 is highly expressed in breast cancer and promotes the metastasis of breast cancer cells. LGALS8-AS1 upregulates SOX12 by sponging miR-125b-5p, thus activating the PI3K/AKT signaling pathway to facilitate breast cancer metastasis. The reciprocal regulatory loop of LGALS8-AS1/miR-125b-5p/SOX12 may serve as a potential therapeutic target for breast cancer treatment.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

miR-92a-3p Promoted EMT via Targeting LATS1 in Cervical Cancer Stem Cells

Shuangyue Liu et al.

Summary: miR-92a-3p is upregulated in cervical cancer tissues and promotes proliferation, invasion and cell cycle transition. LATS1 acts as a tumor suppressor by inhibiting TAZ, E-cadherin, vimentin and cyclin E, and can partly reverse the effects of miR-92a-3p on cancer cell behaviors.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Knockdown of Circ_0000144 Suppresses Cell Proliferation, Migration and Invasion in Gastric Cancer Via Sponging MiR-217

Fengcun Ji et al.

Summary: Gastric cancer is a common malignancy with high incidence and mortality, facing challenges of tumor recurrence, metastasis, and non-specific treatment targets, needing better therapeutic strategies.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

被撤回的出版物: miR-217-5p Inhibits Invasion and Metastasis of Prostate Cancer by Targeting Clusterin (Retracted article. See JUN, 2023)

Wanli Zhao et al.

Summary: miRNA-217-5p inhibits the expression of EMT-related proteins by regulating the expression of the target gene CLU, and further inhibits the invasion and migration of prostate cancer cells such as DU145. This finding provides a theoretical basis for the treatment of prostate cancer.

MAMMALIAN GENOME (2021)

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Article Oncology

Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR-576-5p/PCDH10 axis

Jiahui Zhou et al.

Summary: Hsa_circ_0001666 is downregulated in CRC and its higher expression level is associated with better clinical prognosis. Through regulation of the miR-576-5p/PCDH10 axis, hsa_circ_0001666 suppresses the progression of CRC.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers

Ser Yue Loo et al.

Summary: Clinical trials repurposing PPAR gamma agonists as anticancer agents have shown limited efficacy. Increased expression of PPARG is associated with better prognosis but negatively correlated with HDAC 1 and 2 expressions. Overexpression of HDAC blunts the anti-proliferative and anti-angiogenic responses to PPAR gamma agonists, which can be neutralized with HDAC inhibitors. Combined treatment with HDAC inhibitors is necessary to enhance the tumor-suppressive effects of PPAR gamma agonists in breast cancer cells, including triple-negative and endocrine-refractory subtypes. This combination therapy also inhibits angiogenesis and shows synergistic effects in ER alpha-positive cells.

CELL DEATH DISCOVERY (2021)

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Article Cell Biology

Doxorubicin-induced novel circRNA_0004674 facilitates osteosarcoma progression and chemoresistance by upregulating MCL1 through miR-142-5p

Xiao-Long Ma et al.

Summary: This study identified a novel doxorubicin-induced circular RNA, hsa_circ_0004674, which was upregulated in osteosarcoma chemoresistant cell lines and tissues and correlated with poor prognosis in patients. Knockdown of circ_0004674 inhibited chemoresistance, proliferation, migration, invasion, tumor growth, and induced cell cycle arrest and apoptosis by regulating the expression of the antiapoptotic protein MCL1. Moreover, circ_0004674 could compete with MCL1 for binding to miR-142-5p, suggesting a potential therapeutic target for osteosarcoma.

CELL DEATH DISCOVERY (2021)

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Article Oncology

lncRNA-CASC15 promotes osteosarcoma proliferation and metastasis by regulating epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway

Hongqi Wang et al.

Summary: The study revealed that CASC15 is highly expressed in OS patients and cell lines, promoting cell proliferation and migration while affecting the cell cycle through the activation of the Wnt/beta-catenin pathway. Overexpression of CASC15 in OS cells led to increased metastasis both in vivo and in vitro, with a direct impact on the Wnt pathway and subsequent epithelial-mesenchymal transition.

ONCOLOGY REPORTS (2021)

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Article Developmental Biology

Circ_0015382 is associated with preeclampsia and regulates biological behaviors of trophoblast cells through miR-149-5p/TFPI2 axis

Zongyan Hu et al.

Summary: circ_0015382 is upregulated in PE placenta tissues and suppresses trophoblast cell growth, migration, invasion, and EMT via the miR-149-5p/TFPI2 axis, providing a new understanding of PE pathogenesis and a potential therapeutic target for PE treatment.

PLACENTA (2021)

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Article Oncology

LncRNA HOTAIR recruits SNAIL to inhibit the transcription of HNF4α and promote the viability, migration, invasion and EMT of colorectal cancer

Long Jin et al.

Summary: HOTAIR is highly expressed in colorectal cancer and plays a regulatory role in tumor development. Knocking down HOTAIR inhibits cell viability, migration, invasion, and epithelial-mesenchymal transition in vitro, as well as tumor growth and metastasis in vivo. The suppression of HOTAIR on HNF4a via recruiting SNAIL contributes to its anti-tumor effects.

TRANSLATIONAL ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology

MiR-140-3p Impedes Gastric Cancer Progression and Metastasis by Regulating BCL2/BECN1-Mediated Autophagy

Jianliang Chen et al.

Summary: The research demonstrated that miR-140-3p directly downregulated the expression of BCL2, promoted BECN1 expression, and inhibited EMT in GC cells. These findings suggest that miR-140-3p may act as a tumor suppressor by targeting BCL2 and regulating downstream BECN1-induced autophagy and metastasis in gastric cancer progression.

ONCOTARGETS AND THERAPY (2021)

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Article Biotechnology & Applied Microbiology

miR-944 Suppresses EGF-Induced EMT in Colorectal Cancer Cells by Directly Targeting GATA6

JingTong Tang et al.

Summary: miR-944 influences the malignant phenotype of colorectal cancer (CRC) by regulating epithelial-mesenchymal transition (EMT) and the Wnt/β-catenin signaling pathway. It is negatively associated with UICC stage, lymph nodes, and liver metastasis in CRC, with patients expressing high levels of miR-944 having better survival rates. The miR-944/GATA6 ratio could serve as a novel prognostic biomarker and independent risk prognosis factor in CRC.

ONCOTARGETS AND THERAPY (2021)

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Article Oncology

Exosome-derived miR-210 involved in resistance to osimertinib and epithelial-mesenchymal transition in EGFR mutant non-small cell lung cancer cells

Kakeru Hisakane et al.

Summary: Exosomal miR-210-3p plays a crucial role in resistance to osimertinib in EGFR-mutant NSCLC, by promoting epithelial-mesenchymal transition (EMT) and inducing drug resistance. Further studies are needed to explore the potential of targeting miR-210-3p as a therapeutic strategy for overcoming osimertinib resistance in NSCLC.

THORACIC CANCER (2021)

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Article Oncology

AnnexinA8regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis

Jun-Bin Yuan et al.

Summary: The TUG1/miR-140-3p/ANXA8 axis plays a crucial role in the progression and metastasis of bladder cancer by activating ANXA8, shedding light on the pathogenesis of bladder cancer.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Review Oncology

Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis

Arpita Datta et al.

Summary: The cellular process of EMT is a critical mechanism in cancer metastasis, involving reorganization of the cytoskeleton composed of actin filaments, microtubules, and intermediate filaments. Understanding the physiological functions of the cytoskeleton and targeting key components for EMT regulation may offer promising approaches for cancer therapy, particularly in tackling multidrug-resistant cancer cells.

CANCERS (2021)

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Article Oncology

LncRNA ABCC6P1 promotes proliferation and migration of papillary thyroid cancer cells via Wnt/β-catenin signaling pathway

Yue Guan et al.

Summary: The study revealed that ABCC6P1 plays an oncogenic role in papillary thyroid cancer by regulating the Wnt/beta-catenin pathway, suggesting it as a potential therapeutic target.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

LncRNA RUSC1-AS1 promotes osteosarcoma progression through regulating the miR-340-5p and PI3K/AKT pathway

Chang-Jun Tong et al.

Aging-US (2021)

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Article Pharmacology & Pharmacy

Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway

Fu Li et al.

Summary: The study found that Scutellarin can dose-dependently inhibit the proliferation and metastasis of gastric cancer cells, promote apoptosis, and hinder tumor growth. Additionally, Scutellarin inhibits the PI3K pathway by increasing the expression of PTEN and reducing the phosphorylation level of PI3K, thus suppressing tumor progression.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2021)

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Article Biochemical Research Methods

Circ-ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA-128-3p/ZEB1 axis

Wei Feng et al.

Summary: Our study indicates that depletion of circ-ABCB10 inhibits proliferation, invasion, and EMT, promotes apoptosis of cervical cancer cells through the miR-128-3p/ZEB1 axis, and represses CC tumor growth.

BIOLOGICAL PROCEDURES ONLINE (2021)

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Article Biochemistry & Molecular Biology

miR-219-5p targets TBXT and inhibits breast cancer cell EMT and cell migration and invasion

Qin Ye et al.

Summary: miR-219-5p acts as a tumor suppressor by negatively regulating TBXT expression in breast cancer cells, leading to the inhibition of EMT and cell migration and invasion. Additionally, it also decreases breast cancer stem cell markers' expression and mammosphere forming capability.

BIOSCIENCE REPORTS (2021)

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Article Biochemistry & Molecular Biology

LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition

Lee Kyung Kim et al.

Summary: The study indicates that lncRNA SRA plays an important regulatory role in ovarian cancer, with high expression being closely associated with recurrence-free survival in patients.

BIOSCIENCE REPORTS (2021)

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Review Oncology

Anti-cancer properties of quercetin in osteosarcoma

Parisa Maleki Dana et al.

Summary: Osteosarcoma is a common primary bone tumor in children with unfavorable outcomes despite advances in treatment. Quercetin, a phytochemical compound, has shown promising anti-cancer effects in various cancers, including osteosarcoma, by affecting cell proliferation, apoptosis, invasion, and chemotherapy resistance through regulating protein expression and signaling pathways.

CANCER CELL INTERNATIONAL (2021)

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Article Cell Biology

miR-451 suppresses EMT and metastasis in glioma cells

Yang Nan et al.

Summary: miRNA-451 inhibits the PI3K/Akt/Snail signaling pathway by targeting CAB39, reducing proliferation, invasion, migration, and EMT of glioma cells, potentially serving as a new target for glioma treatment.

CELL CYCLE (2021)

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Article Cell Biology

miR-770-5p regulates EMT and invasion in TNBC cells by targeting DNMT3A

Senem Noyan et al.

Summary: MicroRNA miR-770-5p downregulates Vimentin and Snail expression levels by targeting DNMT3A, while increasing or restoring E-cadherin expression, inhibiting EMT phenotypes, motility, and invasion. Overexpression of miR-770-5p resulted in a loss of mesenchymal characteristics and gain of epithelial phenotype, effectively inhibiting invasion potential driven by EMT.

CELLULAR SIGNALLING (2021)

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Article Cell Biology

LncRNA SNHG12 promotes proliferation and epithelial mesenchymal transition in hepatocellular carcinoma through targeting HEG1 via miR-516a-5p

Ping-Ping Chen et al.

Summary: In this study, it was found that in HCC, SNHG12 promotes EMT by targeting and inhibiting miR-516a-5p, thus upregulating HEG1 expression. Silencing SNHG12 can inhibit proliferation, migration, invasion, and promote apoptosis of HCC cells, while overexpression of SNHG12 produces opposite effects.

CELLULAR SIGNALLING (2021)

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Article Medicine, General & Internal

Circ_0021087 acts as a miR-184 sponge and represses gastric cancer progression by adsorbing miR-184 and elevating FOSB expression

Yin Yu et al.

Summary: Circular RNA circ_0021087 acts as a suppressor in gastric cancer by elevating FOSB expression through adsorbing miR-184, inhibiting malignant behaviors of gastric cancer cells.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Biochemistry & Molecular Biology

LncRNA SNHG20 promotes cell proliferation and invasion by suppressing miR-217 in ovarian cancer

Xuefeng Xing et al.

Summary: SNHG20 is upregulated in ovarian cancer tissues and cell lines, promoting cell proliferation and invasion by sponging miR-217. On the other hand, miR-217 is downregulated in ovarian cancer tissues and cells, negatively regulated by SNHG20, and its overexpression inhibits tumor cell behaviors. These findings suggest that SNHG20 and miR-217 may serve as potential therapeutic targets in ovarian cancer.

GENES & GENOMICS (2021)

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Review Biochemistry & Molecular Biology

Interplay between SOX9 transcription factor and microRNAs in cancer

Milad Ashrafizadeh et al.

Summary: SOX9, a critical transcription factor in the SOXE family, regulates the expression of different transcription factors in cancer cells by binding to miRNAs, affecting cancer progression and malignancy. Other non-coding RNAs can also regulate the expression of miRNA/SOX9 to promote/inhibit cancer progression.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Cell Biology

Long noncoding RNAs in triple-negative breast cancer: A new frontier in the regulation of tumorigenesis

Krishan K. Thakur et al.

Summary: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, primarily affecting younger women. Long noncoding RNAs (lncRNAs) play a crucial role in TNBC treatment, serving as novel diagnostic and prognostic biomarkers. Extensive research is ongoing to uncover the mechanisms through which lncRNAs modulate TNBC progression and treatment.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Oncology

Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK signaling

Fengqiang Yu et al.

Summary: Exosomal miR-31-5p derived from hypoxic LUAD cells plays a crucial role in promoting tumor progression by targeting specific genes and signaling pathways. Higher levels of circulating exosomal miR-31-5p were detected in LUAD patients, particularly those with metastatic disease, suggesting its potential as a diagnostic biomarker for LUAD.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Silencing circ-BIRC6 inhibits the proliferation, invasion, migration and epithelial-mesenchymal transition of bladder cancer cells by targeting the miR-495-3p/XBP1 signaling axis

Lei Zhou et al.

Summary: circ-BIRC6 regulates XBP1 expression by sponging miR-495-3p, leading to suppression of proliferation, invasion, migration, and EMT of bladder cancer cells, as well as significant inhibition of tumor growth.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

Silencing the lncRNA NORAD inhibits EMT of head and neck squamous cell carcinoma stem cells via miR-26a-5p

Weiming Hu et al.

Summary: This study investigated the regulatory role and mechanism of NORAD and miR-26a-5p in the EMT of HNSCC stem cells, demonstrating that NORAD knockdown attenuated the migration, invasion, and EMT of HNSCC stem cells via miR-26a-5p.

MOLECULAR MEDICINE REPORTS (2021)

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Article Biochemistry & Molecular Biology

LncRNA CASC21 induces HGH1 to mediate colorectal cancer cell proliferation, migration, EMT and stemness

Chenxin Zhang et al.

Summary: The study demonstrated that CASC21 enhances the malignancy of CRC by promoting cell proliferation and migration, recruiting POU5F1B, and up-regulating HGH1 expression through competitive sponging of miR-485-5p.

RNA BIOLOGY (2021)

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Article Anatomy & Morphology

miR-934 promotes breast cancer metastasis by regulation of PTEN and epithelial-mesenchymal transition

Yexia Lu et al.

Summary: Breast cancer (BC) is a common and deadly malignancy in females, with over 90% of deaths attributed to tumor metastasis. The study found that elevated expression of miR-934 in BC tissues, especially in cases with lymph node metastasis, was associated with poor prognosis. Results indicated that miR-934 promotes BC cell metastasis by regulating PTEN and EMT, rather than cell growth. Targeting miR-934 may be a promising approach for treating BC metastasis.

TISSUE & CELL (2021)

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Article Biotechnology & Applied Microbiology

miR-593-3p Promotes Proliferation and Invasion in Prostate Cancer Cells by Targeting ADIPOR1

Qiang Huang et al.

Summary: miR-593-3p promotes proliferation, migration, and invasion in PCa cells by targeting ADIPOR1, involving the AMPK signaling pathway and EMT process.

ONCOTARGETS AND THERAPY (2021)

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Article Cell Biology

Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression

Peng Li Zhou et al.

Summary: This study identified the oncogenic role of circPDE3B/miR-4766-5p/LAMA1 axis in promoting ESCC cell proliferation, migration, and invasion by acting as a ceRNA to eliminate the inhibitory effect on LAMA1 and inducing epithelial-mesenchymal transition (EMT). This axis may have potential prognostic and therapeutic significance in ESCC.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Circ-0005105 activates COL11A1 by targeting miR-20a-3p to promote pancreatic ductal adenocarcinoma progression

Gang Ma et al.

Summary: The study reveals that circ-0005105 is upregulated in PDAC tissues and cells, promoting cellular proliferation and invasion. By modulating the miR-20a-3p-COL11A1 axis, circ-0005105 activates epithelial-mesenchymal transition and is associated with malignant clinical phenotype and poor prognosis in PDAC patients.

CELL DEATH & DISEASE (2021)

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Article Oncology

lncRNA LOXL1-AS1 promotes liver cancer cell proliferation and migration by regulating the miR-377-3p/NFIB axis

Wei Yu et al.

Summary: The study revealed that LOXL1-AS1 is significantly upregulated in liver cancer tissues and cells, and is associated with poor clinical outcomes in patients; Knockdown of LOXL1-AS1 suppressed glucose metabolism, proliferation, migration, and EMT in liver cancer cells; LOXL1-AS1 acted as a sponge for miR-377-3p, modulating NFIB to promote glucose metabolism, proliferation, migration, and EMT in liver cancer cells.

ONCOLOGY LETTERS (2021)

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Article Medicine, Research & Experimental

LncRNA FEZF1-AS1 promotes colorectal cancer progression through regulating the miR-363-3p/PRRX1 pathway

Tongtong Zhang et al.

Summary: Our study revealed that FEZF1-AS1 is upregulated in CRC and its silencing can reduce cell proliferation, migration, invasion, and EMT in CRC. We found that FEZF1-AS1 promotes CRC progression by inhibiting miR-363-3p and regulating PRRX1 expression.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2021)

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Article Oncology

Circular RNA Circ_0003221 Promotes Cervical Cancer Progression by Regulating miR-758-3p/CPEB4 Axis

Haihui Xie et al.

Summary: The study revealed that circ_0003221 was upregulated in cervical cancer tissues and cells, and its knockdown inhibited cell proliferation, migration, invasion, and induced cell cycle arrest. MiR-758-3p was confirmed as a direct target of circ_0003221, while CPEB4 was identified as a direct target of miR-758-3p, and miR-758-3p exerted its anti-cancer role by targeting CPEB4. Furthermore, circ_0003221 acted as a sponge of miR-758-3p to upregulate CPEB4 expression, suggesting a potential new insight into the pathogenesis of cervical cancer.

CANCER MANAGEMENT AND RESEARCH (2021)

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Article Oncology

TGF-β-MTA1-SMAD7-SMAD3-SOX4-EZH2 Signaling Axis Promotes Viability, Migration, Invasion and EMT of Hepatocellular Carcinoma Cells

Kangjun Zhang et al.

Summary: The study revealed that EZH2 is upregulated in HCC and correlated with poor prognosis. Silencing EZH2 inhibited HCC cell viability, migration, and invasion, while increasing E-Cadherin expression and decreasing N-Cadherin and Vimentin expression. Additionally, TGF-beta 1 promoted the expression of EZH2 and other signaling molecules, effects which were reversed by silencing EZH2.

CANCER MANAGEMENT AND RESEARCH (2021)

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Article Cell Biology

LncRNA HCP5 Induces Gastric Cancer Cell Proliferation, Invasion, and EMT Processes Through the miR-186-5p/WNT5A Axis Under Hypoxia

Ming Gao et al.

Summary: The study confirmed that the upregulation of WNT5A expression by HCP5 competitively binding to miR-186-5p promotes the development of GC cells. In GC tissues, an increase in HCP5 and WNT5A expressions and a reduction in miR-186-5p expression were found, with a negative correlation between miR-186-5p and HCP5/WNT5A. The inhibition of HCP5 suppressed cell activity and EMT in GC cells under hypoxia, while the inhibition of miR-186-5p or the overexpression of WNT5A had opposite effects.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

LncRNA RP11-499E18.1 Inhibits Proliferation, Migration, and Epithelial-Mesenchymal Transition Process of Ovarian Cancer Cells by Dissociating PAK2-SOX2 Interaction

Juan Yang et al.

Summary: The study identified RP11-499E18.1 as a potential tumor suppressor in ovarian cancer by regulating the RP11-499E18.1-PAK2-SOX2 axis. This suggests RP11-499E18.1 may serve as a diagnostic biomarker for OC in the future.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Neurosciences

circ_ 0082375 promotes the progression of glioma by regulating Wnt7B

Xianbing Meng et al.

Summary: This study revealed that circ_0082375 was upregulated in glioma tissues and closely related to patient prognosis. Knockdown of circ_0082375 inhibited cell proliferation, migration, invasion, angiogenesis, and glycolysis, while promoting apoptosis in glioma cells.

TRANSLATIONAL NEUROSCIENCE (2021)

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Article Biochemistry & Molecular Biology

MicroRNA-196a promotes renal cancer cell migration and invasion by targeting BRAM1 to regulate SMAD and MAPK signaling pathways

Jianzhou Cui et al.

Summary: The study investigated the relationship between miR-196a and BRAM1 in renal cancer using TCGA analysis, RT-PCR, and mouse models, revealing the oncogenic role of miR-196a and tumor-suppressive role of Bram1. Dysregulated miR-196a and Bram1 may serve as potential prognostic biomarkers and therapeutic targets in renal cancer.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Oncology

MiR-182-5p promotes the Metastasis and Epithelial-mesenchymal Transition in Non-small Cell Lung Cancer by Targeting EPAS1

Wenxiao Yang et al.

Summary: miR-182-5p is upregulated in NSCLC tissues and acts as an independent prognostic factor for tumor recurrence in NSCLC patients. It promotes NSCLC progression by targeting EPAS1, which may serve as a potential indicator of tumor recurrence in NSCLC patients.

JOURNAL OF CANCER (2021)

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Article Biotechnology & Applied Microbiology

LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis

Yanqing Feng et al.

Summary: Accumulating evidence suggests that long noncoding RNA (lncRNA) DARS-AS1 plays a role in hepatocellular carcinoma (HCC) by promoting cell proliferation and migration through upregulating CKAP2. Additionally, DARS-AS1 inhibits miR-3200-5p, leading to activation of CKAP2 and the FAK-ERK pathway in HCC. This study highlights DARS-AS1 as a potential target for HCC diagnosis and treatment.

BIOENGINEERED (2021)

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Review Biochemistry & Molecular Biology

MicroRNAs regulating SOX2 in cancer progression and therapy response

Sepideh Mirzaei et al.

Summary: The interaction between miRNAs and SOX2 plays a crucial role in regulating the growth, migration, and therapy response of cancer cells. In addition to miRNAs and SOX2, lncRNAs and circRNAs serve as upstream regulators in this axis. Various molecular pathways, such as NF-kappa B, TNF-alpha, and SOX17, also influence the miRNA/SOX2 axis in cancer.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2021)

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Article Oncology

LncRNA-PVT1 indicates a poor prognosis and promotes angiogenesis via activating the HNF1B/EMT axis in glioma

Yongyan Bi et al.

Summary: Recent studies have shown that lncRNA-PVT1 is significantly upregulated in glioma tissues and plays an important role in cell proliferation, migration, invasion, and angiogenesis. Up-regulation of lncRNA-PVT1 promotes glioma progression both in vitro and in vivo by regulating miR-1207-3p expression. Prediction software was used to identify the regulatory mechanisms of lncRNA-PVT1, miR-1207-3p, and HNF1B, which were validated using a dual-luciferase reporter gene system. This suggests that the lncRNA-PVT1/miR-1207-3p/HNF1B axis may serve as novel molecular targets for glioma prevention and treatment.

JOURNAL OF CANCER (2021)

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Article Oncology

The miR-193a-5p/NCX2/AKT axis promotes invasion and metastasis of osteosarcoma

Ruiqi Chen et al.

Summary: MiR-193a-5p is upregulated in osteosarcoma tissues and promotes colony formation, migration, invasion, and EMT in osteosarcoma cells by targeting NCX2, leading to the progression of osteosarcoma.

JOURNAL OF CANCER (2021)

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Article Biology

Downregulation of circ_0037655 impedes glioma formation and metastasis via the regulation of miR-1229-3p/ITGB8 axis

Wenhui Zou et al.

Summary: The study revealed that downregulation of circ_0037655 expression can inhibit glioma progression by acting on the miR-1229-3p/ITGB8 axis. A specific circ_0037655/miR-1229-3p/ITGB8 axis was disclosed in glioma research, shedding light on potential therapeutic targets for glioma treatment.

OPEN LIFE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

LncRNA EPB41L4A-AS2 represses Nasopharyngeal Carcinoma Metastasis by binding to YBX1 in the Nucleus and Sponging MiR-107 in the Cytoplasm

Mingyu Du et al.

Summary: EPB41L4A-AS2 plays a crucial role in metastasis of nasopharyngeal carcinoma by regulating E-cadherin expression and reversing epithelial-to-mesenchymal transition through its interaction with YBX1 and Snail mRNA stability in the nucleus. Additionally, it inhibits NPC cell invasion and migration by promoting LATS2 expression through sponging miR-107 in the cytoplasm. These findings provide insights into the metastasis mechanism of NPC and offer potential strategies for prevention and treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Cell & Tissue Engineering

Delivery of miR-381-3p Mimic by Mesenchymal Stem Cell-Derived Exosomes Inhibits Triple Negative Breast Cancer Aggressiveness; an In Vitro Study

Samaneh Shojaei et al.

Summary: This study demonstrated that ADMSC-exosomes efficiently delivered miR-381 mimic to MDA-MB-231 cells, leading to significant inhibition of proliferation, migration, and invasion capabilities of triple-negative breast cancer cells, while promoting apoptosis. This suggests that ADMSC-exosomes have the potential to be effective nanocarriers for RNA-based therapies.

STEM CELL REVIEWS AND REPORTS (2021)

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Article Oncology

lncRNA CASC9 sponges miR-758-3p to promote proliferation and EMT in bladder cancer by upregulating TGF-β2

Zeng Zhang et al.

Summary: The long noncoding RNA CASC9 is an oncogenic gene in several types of cancer, including bladder cancer, where it regulates epithelial-mesenchymal transition (EMT). Upregulation of CASC9 is associated with increased invasion ability and poor prognosis in bladder cancer. CASC9 functions as a competing endogenous RNA for miR-758-3p, regulating the expression of TGF-beta 2 and promoting proliferation and EMT in bladder cancer.

ONCOLOGY REPORTS (2021)

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Article Oncology

Effects of miR-93 on epithelial-to-mesenchymal transition and vasculogenic mimicry in triple-negative breast cancer cells

Gaili An et al.

Summary: The study found that miR-93 is significantly upregulated in TNBC, associated with cell invasion and migration, and suppresses EMT by upregulating E-cadherin and occludin and downregulating vimentin and N-cadherin. Additionally, miR-93 may promote VM formation via EMT, making it a potential therapeutic target for TNBC treatment.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR-302-3p on cyclin D1

Wenjing Chen et al.

Summary: In thyroid carcinoma, upregulated ZFAS1 is associated with cell proliferation and affects invasion, migration, invasion, and epithelial-mesenchymal transition by regulating miR-302a-3p and CCND1. Downregulation of ZFAS1 can reduce these malignant biological processes.

MOLECULAR MEDICINE REPORTS (2021)

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Article Chemistry, Multidisciplinary

Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis

Tong Sun et al.

Summary: Recent studies have shown that the expression of CCND1 and the dysregulation of USP10 play crucial roles in glioma progression. Interactions between CCND1 and USP10 affect cell cycle control and apoptosis in GBM cells, highlighting their potential as therapeutic targets for GBM patients. The natural product acevaltrate (AVT) derived from Valeriana jatamansi Jones has shown promising effects in inducing GBM cell apoptosis by suppressing USP10-mediated deubiquitination on CCND1.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Medicine, General & Internal

SATB1 Knockdown Inhibits Proliferation and Invasion and Decreases Chemoradiation Resistance in Nasopharyngeal Carcinoma Cells by Reversing EMT and Suppressing MMP-9

Dongni Zhou et al.

Summary: The study showed that SATB1 plays a crucial role in promoting drug and radiation resistance in NPC by enhancing MMP-9 expression and promoting the EMT process. This suggests that SATB1 could be a potential therapeutic target for aggressive and chemoradiation resistant NPC.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

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Article Oncology

Shikonin inhibits migration and invasion of triple-negative breast cancer cells by suppressing epithelial-mesenchymal transition via miR-17-5p/PTEN/Akt pathway

Chang Bao et al.

Summary: The study demonstrated that shikonin inhibits the migration and invasion of triple-negative breast cancer cells by suppressing EMT through the miR-17-5p/PTEN/Akt pathway, suggesting its potential as a therapeutic agent to counteract metastasis in TNBC patients.

JOURNAL OF CANCER (2021)

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Article Biotechnology & Applied Microbiology

MiR-155-5p promotes metastasis and epithelial-mesenchymal transition of renal cell carcinoma by targeting apoptosis-inducing factor

Qing-qing Lei et al.

Summary: miR-155-5p is significantly elevated in renal cancer tissues and cells, suppressing miR-155-5p can decrease tumor growth, migration, and invasion, while overexpression of miR-155-5p leads to opposite effects by targeting the apoptosis-inducing factor.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2021)

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Article Oncology

Circ_0032821 acts as an oncogene in cell proliferation, metastasis and autophagy in human gastric cancer cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway

Yuanyuan Jiang et al.

CANCER CELL INTERNATIONAL (2020)

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Review Pharmacology & Pharmacy

Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and metaflammation: Therapeutic targets for obesity and type 2 diabetes

Khurram Aamir et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Oncology

Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective

Mei Shan Ong et al.

CANCERS (2020)

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Article Genetics & Heredity

Circ_0000267 promotes gastric cancer progression via sponging MiR-503-5p and regulating HMGA2 expression

Xiaopeng Cai et al.

MOLECULAR GENETICS & GENOMIC MEDICINE (2020)

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Review Biochemistry & Molecular Biology

The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

Xuejiao Chen et al.

BIOMOLECULES (2020)

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Article Medicine, Research & Experimental

MiR-451a attenuates doxorubicin resistance in lung cancer via suppressing epithelialmesenchymal transition (EMT) through targeting c-Myc

Li Tao et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Oncology

MiR-200c-3p suppression is associated with development of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutant non-small cell lung cancer via a mediating epithelial-to-mesenchymal transition (EMT) process

Hsin-Yi Wang et al.

CANCER BIOMARKERS (2020)

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Article Oncology

LncRNA NNT-AS1 contributes to the cisplatin resistance of cervical cancer through NNT-AS1/miR-186/HMGB1 axis

Yanjie Liu et al.

CANCER CELL INTERNATIONAL (2020)

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Article Biotechnology & Applied Microbiology

Hsa_circ_0043265 Suppresses Proliferation, Metastasis, EMT and Promotes Apoptosis in Non-Small Cell Lung Cancer Through miR-25-3p/FOXP2 Pathway

Tiejun Ren et al.

ONCOTARGETS AND THERAPY (2020)

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Article Biotechnology & Applied Microbiology

Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis

Jianjun Liu et al.

ONCOTARGETS AND THERAPY (2020)

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Article Biotechnology & Applied Microbiology

lncRNA MALATI Promotes EMT Process and Cisplatin Resistance of Oral Squamous Cell Carcinoma via PI3K/AKT/m-TOR Signal Pathway

Ran Wang et al.

ONCOTARGETS AND THERAPY (2020)

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Article Oncology

MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma

Pierre-Antoine Bissey et al.

BMC CANCER (2020)

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Review Oncology

Non-coding RNA in bladder cancer

Yi Li et al.

CANCER LETTERS (2020)

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Review Cell Biology

Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer

Samarth Kansara et al.

CELLS (2020)

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Article Multidisciplinary Sciences

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma

Jong Hyun Lee et al.

JOURNAL OF ADVANCED RESEARCH (2020)

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Article Oncology

Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging miR-143-3p and PCBP1

Li-na Song et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Pivalopril improves anti-cancer efficiency of cDDP in breast cancer through inhibiting proliferation, angiogenesis and metastasis

Li Fei et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Medicine, Research & Experimental

Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/β-catenin pathway

Min Zhao et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Oncology

Circular RNA circ-CPA4/let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)

Weijun Hong et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Medicine, Research & Experimental

circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m6A-YTHDF3-Zeb1

Maoyu Wang et al.

LIFE SCIENCES (2020)

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Article Biochemistry & Molecular Biology

High-metastatic cancer cells derived exosomal miR92a-3p promotes epithelial-mesenchymal transition and metastasis of low-metastatic cancer cells by regulating PTEN/Akt pathway in hepatocellular carcinoma

Beng Yang et al.

ONCOGENE (2020)

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Article Biotechnology & Applied Microbiology

被撤回的出版物: LncRNA LINC01116 Contributes to Cisplatin Resistance in Lung Adenocarcinoma (Retracted article. See vol. 16, pg. 615, 2023)

Junbin Wang et al.

ONCOTARGETS AND THERAPY (2020)

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Article Cell Biology

Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma

Wencheng Dai et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

Circular RNA circ-0016068 Promotes the Growth, Migration, and Invasion of Prostate Cancer Cells by Regulating the miR-330-3p/BMI-1 Axis as a Competing Endogenous RNA

Qingyuan Li et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade

Sun Tae Hwang et al.

BIOMOLECULES (2020)

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Article Oncology

LncRNA ST7-AS1, by regulating miR-181b-5p/KPNA4 axis, promotes the malignancy of lung adenocarcinoma

Rong-Hang Hu et al.

CANCER CELL INTERNATIONAL (2020)

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Article Cell Biology

Downregulation of cytokeratin 18 induces cellular partial EMT and stemness through increasing EpCAM expression in breast cancer

Ruizan Shi et al.

CELLULAR SIGNALLING (2020)

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Article Biotechnology & Applied Microbiology

The lncRNA LINC0069/Functions as a ceRNA for miRNA-1256 to Suppress Osteosarcoma by Regulating the Expression of ST5

Daqian Wan et al.

ONCOTARGETS AND THERAPY (2020)

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Article Oncology

LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network

Cristina Barbagallo et al.

CANCERS (2020)

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Article Oncology

miR-325-3p Promotes the Proliferation, Invasion, and EMT of Breast Cancer Cells by Directly Targeting S100A2

Huiling Wang et al.

ONCOLOGY RESEARCH (2020)

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Article Cell & Tissue Engineering

LncRNA DLX6-AS1 Contributes to Epithelial-Mesenchymal Transition and Cisplatin Resistance in Triple-negative Breast Cancer via Modulating Mir-199b-5p/Paxillin Axis

Chuang Du et al.

CELL TRANSPLANTATION (2020)

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Article Cell Biology

LncRNA SNHG3 induces EMT and sorafenib resistance by modulating the miR-128/CD151 pathway in hepatocellular carcinoma

Peng-Fei Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

The expanding roles of long non-coding RNAs in the regulation of cancer stem cells

Zhaowu Ma et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

被撤回的出版物: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer (Retracted article. See vol. 21, 2022)

Tong Liu et al.

MOLECULAR CANCER (2019)

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Article Oncology

Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade

Jong Hyun Lee et al.

CANCERS (2019)

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Article Biochemistry & Molecular Biology

Encapsulated human mesenchymal stem cells (eMSCs) as a novel anti-cancer agent targeting breast cancer stem cells: Development of 3D primed therapeutic MSCs

Saurabh Mandal et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade

Min Hee Yang et al.

MOLECULES (2019)

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Article Medicine, Research & Experimental

circ-CSPP1 promotes proliferation, invasion and migration of ovarian cancer cells by acting as a miR-1236-3p sponge

Qian-hui Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Plant Sciences

Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells

Sun Tae Hwang et al.

PHYTOMEDICINE (2019)

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Article Medical Laboratory Technology

Hsa_circ_101882 promotes migration and invasion of gastric cancer cells by regulating EMT

Gui-Hua Yin et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2019)

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Article Pharmacology & Pharmacy

Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism(s) in tumor models

Clarissa Esmeralda Halim et al.

PHARMACOLOGICAL RESEARCH (2019)

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Review Cell Biology

Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition

Jun-Ting Cheng et al.

CELLS (2019)

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Article Biotechnology & Applied Microbiology

circ-MYBL2 Serves As A Sponge For miR-361-3p Promoting Cervical Cancer Cells Proliferation And Invasion

Jinrong Wang et al.

ONCOTARGETS AND THERAPY (2019)

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Article Cell Biology

LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization

Zhen-xing Liang et al.

CELL DEATH & DISEASE (2019)

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Article Multidisciplinary Sciences

c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

Wen Jing Sim et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Sema4C mediates EMT inducing chemotherapeutic resistance of miR-31-3p in cervical cancer cells

Li Jing et al.

SCIENTIFIC REPORTS (2019)

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Review Biochemistry & Molecular Biology

Role of tumor-derived exosomes in cancer metastasis

Ian Wee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Article Cell Biology

Hsa_circ_0006938 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma

Zihao Pan et al.

AGING-US (2019)

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Article Cell Biology

The contrary functions of lncRNA HOTAIR/miR-17-5p/PTEN axis and Shenqifuzheng injection on chemosensitivity of gastric cancer cells

Jianguang Jia et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of STAT3 signaling cascade

Jong Hyun Lee et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer

Huaying Dong et al.

MOLECULAR CANCER (2019)

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Article Pharmacology & Pharmacy

Farnesol abrogates epithelial to mesenchymal transition process through regulating Akt/mTOR pathway

Jong Hyun Lee et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Oncology

Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma

Gurubharathi Bhuvanalakshmi et al.

CANCERS (2019)

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Article Oncology

Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model

Young Yun Jung et al.

CANCERS (2019)

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Article Biotechnology & Applied Microbiology

Exosome-Mediated Transfer of lncRNA HOTTIP Promotes Cisplatin Resistance in Gastric Cancer Cells by Regulating HMGAI/miR-218 Axis

Jingyu Wang et al.

ONCOTARGETS AND THERAPY (2019)

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Review Biochemistry & Molecular Biology

Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases

Shruti Mishra et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Biotechnology & Applied Microbiology

miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer

Xinliang Zhou et al.

CANCER GENE THERAPY (2018)

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Article Oncology

Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling

Lingzhi Wang et al.

CANCER LETTERS (2018)

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Review Oncology

Novel tumor necrosis factor-alpha induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression

Ganesan Padmavathi et al.

CANCER LETTERS (2018)

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Article Oncology

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

Chulwon Kim et al.

CANCER LETTERS (2018)

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Article Genetics & Heredity

Hsa_circ_0079530 promotes cell proliferation and invasion in non-small cell lung cancer

Jipeng Li et al.

GENE (2018)

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Article Cell Biology

miR-1-3p and miR-206 sensitizes HGF-induced gefitinib-resistant human lung cancer cells through inhibition of c-Met signalling and EMT

Demin Jiao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Article Biotechnology & Applied Microbiology

miR-145 Antagonizes SNAI1-Mediated Sternness and Radiation Resistance in Colorectal Cancer

Yun Zhu et al.

MOLECULAR THERAPY (2018)

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Article Biochemistry & Molecular Biology

Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition

Jeong-Hyeon Ko et al.

MOLECULES (2018)

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Article Biochemistry & Molecular Biology

Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin β3

Jinnan Yue et al.

ONCOGENE (2018)

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Article Oncology

MiR-21 improves invasion and migration of drug-resistant lung adenocarcinoma cancer cell and transformation of EMT through targeting HBP1

Chongyu Su et al.

CANCER MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-beta-induced epithelial- mesenchymal transition and metastasis by controlling TIF1 gamma in non-small cell lung cancer

Longqiang Wang et al.

MOLECULAR CANCER (2018)

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Article Pharmacology & Pharmacy

Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis

Muthu K. Shanmugam et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Oncology

Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma

Jong Hyun Lee et al.

CANCERS (2018)

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Review Oncology

Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance

Azhwar Raghunath et al.

CANCERS (2018)

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Review Oncology

Non-coding RNA networks in cancer

Eleni Anastasiadou et al.

NATURE REVIEWS CANCER (2018)

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Article Biochemistry & Molecular Biology

Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer

Jingwen Zhang et al.

APOPTOSIS (2017)

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Review Oncology

Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma

Supritha G. Swamy et al.

TARGETED ONCOLOGY (2017)

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Article Oncology

Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer

Jiahui Xu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

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Article Oncology

iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling

Ying Xiong et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

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Review Oncology

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers

Wanpei Cai et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Article Oncology

PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Luxi Chen et al.

MOLECULAR CANCER THERAPEUTICS (2017)

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Article Oncology

miR-375 inhibits cancer stem cell phenotype and tamoxifen resistance by degrading HOXB3 in human ER-positive breast cancer

Hui Fu et al.

ONCOLOGY REPORTS (2017)

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Article Biotechnology & Applied Microbiology

Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells

Jin Li et al.

ONCOTARGETS AND THERAPY (2017)

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Review Oncology

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers

Wanpei Cai et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Article Pharmacology & Pharmacy

Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4

G. Bhuvanalakshmi et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Review Pharmacology & Pharmacy

'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling

Mei S. Ong et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Review Oncology

Small non-coding RNA and cancer

Giulia Romano et al.

CARCINOGENESIS (2017)

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Article Oncology

Potential role of targeted therapies in the treatment of triple-negative breast cancer

Lee Yueh Jia et al.

ANTI-CANCER DRUGS (2016)

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Article Biochemistry & Molecular Biology

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

Jingwen Zhang et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

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Article Oncology

A novel combinatorial strategy using Seliciclib® and Belinostat® for eradication of non-small cell lung cancer via apoptosis induction and BID activation

Pei-Shi Ong et al.

CANCER LETTERS (2016)

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Article Oncology

Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma

Xiaoyun Dai et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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Article Plant Sciences

Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

Seung Ho Baek et al.

PHYTOMEDICINE (2016)

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Article Multidisciplinary Sciences

Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

Chakrabhavi Dhananjaya Mohan et al.

PLOS ONE (2016)

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Review Pharmacology & Pharmacy

Exosome-Mediated Metastasis: From Epithelial-Mesenchymal Transition to Escape from Immunosurveillance

Nicholas Syn et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

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Article Oncology

MicroRNA-130b promotes proliferation and EMT-induced metastasis via PTEN/p-AKT/HIF-1α signaling

Rui-Min Chang et al.

TUMOR BIOLOGY (2016)

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Article

Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer

Jong Hyun Lee et al.

Oncotarget (2016)

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Review Pharmacology & Pharmacy

Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

Pei Shi Ong et al.

FRONTIERS IN PHARMACOLOGY (2016)

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Review Oncology

Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review

Jeanetta K. Mastron et al.

ANTI-CANCER DRUGS (2015)

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Article Oncology

Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway

Jong Hyun Lee et al.

CANCER LETTERS (2015)

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Article Oncology

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