☆ 4.7 Article

IKs inhibitor JNJ303 prolongs the QT interval and perpetuates arrhythmia when combined with enhanced inotropy in the CAVB dog

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Related references

Note: Only part of the references are listed.

Review Pharmacology & Pharmacy

The canine chronic atrioventricular block model in cardiovascular preclinical drug research

Vera Loen et al.

Summary: The article highlights the importance of ventricular cardiac arrhythmia and animal models in predicting drug effects, focusing on the chronic atrioventricular block (CAVB) model in dogs and summarizing its role and development in cardiovascular research. Data obtained from CAVB dogs are crucial for understanding the mechanisms of arrhythmias and drug efficacy.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Left Cardiac Sympathetic Denervation for Long QT Syndrome 50 Years' Experience Provides Guidance for Management

Veronica Dusi et al.

Summary: This study retrospectively reports the single-center experience of left cardiac sympathetic denervation (LCSD) for long QT syndrome (LQTS) since 1973. LCSD was performed in 125 patients with LQTS and a mean follow-up of 12.9 years. The study provides evidence for the long-term efficacy of LCSD in LQTS, showing a significant decrease in cardiac events and symptom improvement in most patient groups after the procedure. The degree of antiarrhythmic protection is influenced by the patient's QTc shortening.

JACC-CLINICAL ELECTROPHYSIOLOGY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

Hugo M. Vargas et al.

Summary: Efficient assessment of drug-induced QTc prolongation remains a concern of drug developers and regulators worldwide. While successful, nonclinical evaluations currently have minimal impact on clinical QTc prolongation assessment. Fully integrating nonclinical and clinical data can simplify drug development processes.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decision Making for QTc and Proarrhythmia Risk (ICH E14/S7B Updates)

David G. Strauss et al.

Summary: After certain drugs were withdrawn from the market due to the risk of drug-induced torsade de pointes (TdP), the ICH released guidelines focusing on the assessment of surrogate biomarkers for TdP in 2005. Vargas et al. proposed that double-negative nonclinical data may not require detailed clinical QTc evaluation due to low probability of QTc prolongation and TdP, leading to the ICH releasing a new Draft Guideline to address this. The ICH's new guidelines aim to reduce Thorough QT (TQT) studies using double-negative nonclinical data and achieving a low-risk determination in situations where TQT studies are not feasible.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

Add to Collection

Article Physiology

Severe Bradycardia Increases the Incidence and Severity of Torsade de Pointes Arrhythmias by Augmenting Preexistent Spatial Dispersion of Repolarization in the CAVB Dog Model

Valerie Y. H. van Weperen et al.

Summary: In the chronic atrioventricular block (CAVB) dog model, severe bradycardia increases the probability and severity of arrhythmic events by heterogeneously causing electrophysiological instability, mainly reflected in an increased spatial dispersion of repolarization.

FRONTIERS IN PHYSIOLOGY (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Interplay between temporal and spatial dispersion of repolarization in the initiation and perpetuation of torsades de pointes in the chronic atrioventricular block dog

Agnieszka Smoczynska et al.

Summary: This study compared the temporal and spatial dispersion of repolarization in the arrhythmogenesis of torsades de pointes arrhythmias. It found that an increase in temporal dispersion contributes to the initiation of single ectopic beats, while an increase in spatial dispersion is important for the perpetuation of non-self-terminating torsades de pointes arrhythmias.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Add to Collection

Article Pharmacology & Pharmacy

Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model

Henk van der Linde et al.

Summary: The study found that proconvulsive drugs can trigger TdP-like cardiac arrhythmias in conditions of compromised repolarization in the heart, increasing the risk of SUDEP in epileptic patients.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2021)

Add to Collection

Review Anesthesiology

Respiratory Physiology for the Anesthesiologist

Luca Bigatello et al.

ANESTHESIOLOGY (2019)

Add to Collection

Article Cardiac & Cardiovascular Systems

The Increment of Short-term Variability of Repolarisation Determines the Severity of the Imminent Arrhythmic Outcome

Agnieszka Smoczynska et al.

ARRHYTHMIA & ELECTROPHYSIOLOGY REVIEW (2019)

Add to Collection

Article Physiology

An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog

David J. Sprenkeler et al.

FRONTIERS IN PHYSIOLOGY (2018)

Add to Collection

Review Cardiac & Cardiovascular Systems

Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog

Alexandre Bossu et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2017)

Add to Collection

Article Physiology

cAMP-dependent regulation of IKs single-channel kinetics

Emely Thompson et al.

JOURNAL OF GENERAL PHYSIOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle

C. Kang et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

Evolution of strategies to improve preclinical cardiac safety testing

Gary Gintant et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Add to Collection

Article Pharmacology & Pharmacy

Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

L. Johannesen et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2014)

Add to Collection

Article Cardiac & Cardiovascular Systems

Novel Parameters to Improve Quantification of Repolarization Reserve and Arrhythmogenesis Using a Dofetilide Challenge

T.R.G. Stams et al.

HEART RHYTHM (2013)

Add to Collection

Article Neurosciences

Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs

Norbert Jost et al.

JOURNAL OF PHYSIOLOGY-LONDON (2013)

Add to Collection

Article Pharmacology & Pharmacy

The Electro-Mechanical window: a risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias

H. J. van der Linde et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Add to Collection

Article Pharmacology & Pharmacy

Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action

A. Oros et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Add to Collection

Article Cardiac & Cardiovascular Systems

Anesthesia and Arrhythmogenesis in the Chronic Atrioventricular Block Dog Model

Albert Dunnink et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2010)

Add to Collection

Article Pharmacology & Pharmacy

Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?

Rob Towart et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2009)

Add to Collection

Article Cardiac & Cardiovascular Systems

In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome

David J. Gallacher et al.

CARDIOVASCULAR RESEARCH (2007)

Add to Collection

Article Cardiac & Cardiovascular Systems

Dispersion of repolarization in canine ventricle and the electrocardiographic T wave:: Tp-e interval does not reflect transmural dispersion

Tobias Opthof et al.

HEART RHYTHM (2007)

Add to Collection

Article Cardiac & Cardiovascular Systems

Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

MB Thomsen et al.

CIRCULATION (2004)

Add to Collection

Article Cardiac & Cardiovascular Systems

Probing the contribution of IKs to canine ventricular repolarization -: Key role for β-adrenergic receptor stimulation

PGA Volders et al.

CIRCULATION (2003)

Add to Collection

Article Anesthesiology

The effects of lsoflurane on the cardiac slowly activating delayed-rectifier potassium channel in guinea pig ventricular myocytes

A Suzuki et al.

ANESTHESIA AND ANALGESIA (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.