Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 178, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejps.2022.106284
Keywords
Abdominal aortic aneurysm; Statins; Inflammation; Oxidative stress; Extracellular matrix
Categories
Ask authors/readers for more resources
This article reviews different studies and summarizes potential mechanisms by which statins can have an effect on abdominal aortic aneurysm (AAA). The evidence suggests an association between treatment with statins and improvement of AAA.
Abdominal aortic aneurysm (AAA) is a prevalent condition which causes progressive growth and rupture of aortic wall with a high death rate. Several studies have found that treatment with statins may decrease the progress of AAA and the risk of rupture by suppressing the inflammatory mediators, decreasing oxidative stress, and inhibiting mechanisms involved in extracellular matrix (ECM) degradation. Moreover, some studies have reported that prehospital therapy with statins can decrease mortality after surgery. The novelty of this paper is that different studies including those performed in humans and animals were reviewed and the potential mechanisms by which statins can have an effect on AAA were summarized. Overall, the evidence suggested an association between treatment with statins and improvement of AAA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available