Journal
EUROPEAN JOURNAL OF ONCOLOGY NURSING
Volume 61, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejon.2022.102230
Keywords
Radiotherapy; Breast neoplasms; Radiodermatitis; Prevention; Nursing care; Oncology nursing; Free radicals; Antioxidants; Vitamin E; Nanotechnology; Enterostomal Therapy
Funding
- Coordination for the Improvement of Higher Education Personnel (Coordena?a?o de Aperfei?oamento de Pes-soal de Nivel Superior-CAPES) [001]
- National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq)
- Federal Institute for Education, Science, and Technology of the South of Minas Gerais
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This study evaluated the effect of a vitamin E-containing nanoparticle cream as an antioxidant for preventing radiodermatitis. The results showed that the cream had a protective effect on the onset time of radiodermatitis in patients who did not receive a boosted radiation dose, and it also reduced the occurrence of mild inframammary erythema.
Purpose: Most topical agents for radiodermatitis prevention are not based on its pathophysiology, mainly caused by the indirect effects of radiation from reactive oxygen species release. Therefore, this study aimed to evaluate the effect of vitamin E-containing nanoparticle cream as an antioxidant for radiodermatitis prevention.Method: A randomized, triple-blind, parallel pilot study conducted in an Oncology Hospital including 40 adult women with breast cancer, and healthy skin, submitted to radiotherapy, divided into three groups: Intervention (12; 30%) receiving cream with nanoparticles containing vitamin E; Control 1 (14; 35%) cream without nano-particles or vitamin E; Control 2 (14; 35%) cream with nanoparticles without vitamin E. Incidence, grade and time to onset of radiodermatitis were primary outcomes; health-related quality of life, reported symptoms, and breast temperature were secondary outcomes.Results: All patients were followed until the end of the study. All had radiodermatitis. There were no significant differences between the study groups regarding radiodermatitis grade, health-related quality of life, and breast temperatures. A protective effect of vitamin E-containing nanoparticle cream was identified regarding the onset time of radiodermatitis in patients who did not receive a boosted radiation dose (p = .03) and the occurrence of mild inframammary erythema (p = .04). Itching was reported by 90% of the women. The definitive calculated sample is 108 volunteers. There were no identified side effects.Conclusions: A potential protective effect of a cream containing vitamin E nanoparticles was observed. This pilot study presents initial evidence about the role of a nanoencapsulated antioxidant in preventing radiodermatitis.Trial registration: No. RBR-784F3Y; UTN-U1111-1201-5923.
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