4.7 Article

Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia

Related references

Note: Only part of the references are listed.
Article Neurosciences

Associations Between MRI-Assessed Locus Coeruleus Integrity and Cortical Gray Matter Microstructure

Jeremy A. Elman et al.

Summary: The integrity of the locus coeruleus (LC) is associated with cortical gray matter microstructure, reflecting broader neurodegenerative processes. This suggests that LC imaging and advanced diffusion measures can be useful in evaluating brain health and identifying early stages of neurodegeneration.

CEREBRAL CORTEX (2022)

Review Clinical Neurology

Locus Coeruleus Magnetic Resonance Imaging in Neurological Diseases

Alessandro Galgani et al.

Summary: LC-MRI studies have shown that LC signal is minimally affected during normal aging, but significantly reduced in patients with neurodegenerative diseases, making it a potential early biomarker.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2021)

Article Clinical Neurology

A case-control study of the locus coeruleus degeneration in Alzheimer's disease

Ruihua Hou et al.

Summary: This study is the largest individually-matched case-control study to visualize the locus coeruleus degeneration in Alzheimer's disease patients, revealing significant LC degeneration which holds promise for stratifying patients for treatment targeting noradrenergic dysfunction.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2021)

Article Clinical Neurology

MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction

Jeremy A. Elman et al.

Summary: The study found that reduced LC integrity is associated with widespread differences across cognitive domains, daytime sleep-related dysfunction, and increased risk for aMCI. These findings highlight the potential of MRI-based measures of LC integrity in early identification of AD risk in late-middle-aged adults.

ALZHEIMERS & DEMENTIA (2021)

Article Geriatrics & Gerontology

Locus coeruleus MRI contrast is associated with cortical thickness in older adults

Shelby L. Bachman et al.

Summary: The study found a positive relationship between LC contrast and cortical thickness in older adults, particularly in the parietal, frontal, and occipital regions. This suggests a link between LC structure and cortical brain structure in later adulthood.

NEUROBIOLOGY OF AGING (2021)

Review Neurosciences

Sex Differences in Locus Coeruleus: A Heuristic Approach That May Explain the Increased Risk of Alzheimer's Disease in Females

Alison M. Luckey et al.

Summary: This article revisits the vulnerability of females to Alzheimer's disease and proposes a new hypothesis on the role of sex differences in the locus coeruleus-noradrenaline system. It highlights the importance of investigating the locus coeruleus morphology, estrogen levels, neuroinflammation, blood-brain barrier permeability, APOE epsilon 4 polymorphism, and cognitive reserve in relation to AD vulnerability. The article suggests that a precision medicine approach may be necessary to develop distinct treatments for females and males with Alzheimer's disease.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Cell Biology

In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline

Heidi I. L. Jacobs et al.

Summary: Various autopsy studies have shown that the locus coeruleus (LC) is the initial site of hyperphosphorylated TAU aggregation, and as TAU accumulates in LC neurons, pathology spreads throughout the cortex. Lower LC integrity is associated with increased TAU deposition in the entorhinal cortex in older individuals, and LC pigmentation ratings correlate with LC neuronal density, particularly in advanced Braak stages. These findings suggest that LC integrity may be a promising indicator of early Alzheimer's disease processes and cognitive changes.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Review Neurosciences

Locus coeruleus: a new look at the blue spot

Gina R. Poe et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Article Geriatrics & Gerontology

In vivo visualization of age-related differences in the locus coeruleus

Kathy Y. Liu et al.

NEUROBIOLOGY OF AGING (2019)

Article Clinical Neurology

Early alteration of the locus coeruleus in phenotypic variants of Alzheimer's disease

Pauline Olivieri et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

Article Psychology, Biological

Rostral locus coeruleus integrity is associated with better memory performance in older adults

Martin J. Dahl et al.

NATURE HUMAN BEHAVIOUR (2019)

Article Clinical Neurology

Locus coeruleus MRI contrast is reduced in Alzheimer's disease dementia and correlates with CSF Aβ levels

Matthew J. Betts et al.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2019)

Review Behavioral Sciences

Magnetic resonance imaging of the human locus coeruleus: A systematic review

Kathy Y. Liu et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Article Neurosciences

Locus coeruleus cellular and molecular pathology during the progression of Alzheimer's disease

Sarah C. Kelly et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)

Article Social Sciences, Mathematical Methods

Factor Score Path Analysis An Alternative for SEM?

Ines Devlieger et al.

METHODOLOGY-EUROPEAN JOURNAL OF RESEARCH METHODS FOR THE BEHAVIORAL AND SOCIAL SCIENCES (2017)

Article Biochemistry & Molecular Biology

Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system

Douglas L. Feinstein et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Volume Transmission in Central Dopamine and Noradrenaline Neurons and Its Astroglial Targets

Kjell Fuxe et al.

NEUROCHEMICAL RESEARCH (2015)

Review Clinical Neurology

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

Bruno Dubois et al.

LANCET NEUROLOGY (2014)

Article Clinical Neurology

Higher Rates of Decline for Women and Apolipoprotein E ε4 Carriers

D. Holland et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2013)

Article Biochemistry & Molecular Biology

Oxidative stress and APO E polymorphisms in Alzheimer's disease and in mild cognitive impairment

L. Chico et al.

FREE RADICAL RESEARCH (2013)

Article Clinical Neurology

Neural reserve, neuronal density in the locus ceruleus, and cognitive decline

Robert S. Wilson et al.

NEUROLOGY (2013)

Article Anatomy & Morphology

The human locus coeruleus 3-D stereotactic anatomy

P. Fernandes et al.

SURGICAL AND RADIOLOGIC ANATOMY (2012)

Article Neurosciences

Grey-Matter Atrophy in Alzheimer's Disease is Asymmetric but not Lateralized

Sabine Derflinger et al.

JOURNAL OF ALZHEIMERS DISEASE (2011)

Article Biochemistry & Molecular Biology

Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits

Daniel Jardanhazi-Kurutz et al.

NEUROCHEMISTRY INTERNATIONAL (2010)

Article Multidisciplinary Sciences

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

Michael T. Heneka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Neurosciences

The locus coeruleus and noradrenergic modulation of cognition

Susan J. Sara

NATURE REVIEWS NEUROSCIENCE (2009)