4.6 Article

Angiopoietins, vascular endothelial growth factors and secretory phospholipase A2 in heart failure patients with preserved ejection fraction

Related references

Note: Only part of the references are listed.
Review Medicine, General & Internal

Heart failure with preserved ejection fraction: Squaring the circle between comorbidities and cardiovascular abnormalities

Alberto Maria Marra et al.

Summary: HFpEF is a major healthcare issue with a high degree of disease heterogeneity, making it difficult to demonstrate the impact of drugs on morbidity and mortality in clinical trials.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2022)

Article Medicine, General & Internal

Phenotyping congestion in patients with acutely decompensated heart failure with preserved and reduced ejection fraction: The Decongestion duRing therapY for acute decOmpensated heart failure in HFpEF vs HFrEF-DRY-OFF study

C. Cogliati et al.

Summary: This study aims to evaluate pulmonary and intravascular congestion in patients with acute decompensated heart failure (ADHF) using lung and inferior vena cava ultrasound. The results show that patients with HFrEF had higher indexes of pulmonary and intravascular congestion at admission and discharge. Furthermore, HFrEF patients had a greater reduction in intravascular venous congestion with diuretic treatment compared to HFpEF patients.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2022)

Review Cardiac & Cardiovascular Systems

Heart failure with mid-range or mildly reduced ejection fraction

Gianluigi Savarese et al.

Summary: HFmrEF, a subtype of heart failure, accounts for 25% of patients with heart failure, and has been relatively less explored compared to HFrEF and HFpEF. Patients with HFmrEF have milder symptoms and lower risk of cardiovascular events compared to those with HFrEF, but similar or greater risk of non-cardiovascular adverse events. Studies suggest that drugs effective in HFrEF patients may also be effective in HFmrEF patients.

NATURE REVIEWS CARDIOLOGY (2022)

Review Medicine, General & Internal

From mid-range to mildly reduced ejection fraction heart failure: A call to treat

Davide Stolfo et al.

Summary: Historically, heart failure (HF) has been classified into two distinct subgroups based on ejection fraction (EF), HF with reduced EF (HFrEF) and HF with preserved EF (HFpEF). However, recent research has shown potential benefits of new therapies for patients with EF between 41% and 49%, leading to the renaming of this subgroup as HF with mildly reduced EF (HFmrEF). This review discusses the reasons behind this modification, summarizes the characteristics of HFmrEF and its similarities and differences with the other EF categories, and provides a comprehensive overview of the current available evidence supporting the treatment of patients with HFmrEF.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2022)

Article Medicine, Research & Experimental

Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation

Kristofor E. Glinton et al.

Summary: Clearance of dying cells by efferocytosis is crucial for cardiac repair after myocardial infarction (MI). In this study, it was found that defective efferocytosis by macrophages after MI led to a reduction in cardiac lymphangiogenesis and Vegfc expression. Cardiac macrophages promoted myocardial lymphangiogenesis and suppressed inflammatory cytokines through the production of Vegfc.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Cell Biology

LPS-mediated neutrophil VEGF-A release is modulated by cannabinoid receptor activation

Mariantonia Braile et al.

Summary: Neutrophils play a central role in inflammation and tumor angiogenesis by releasing angiogenic factors. This study found that CB agonists can modulate the release of VEGF-A from LPS-activated PMNs, indicating a potential novel therapeutic strategy for patients with sepsis.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction

Virginia S. Hahn et al.

Summary: The study revealed distinctive transcriptomic signatures and molecular subgroupings in patients with HFpEF, with specific clinical features and outcomes. Obesity was found to be a major contributor to the upregulation of genes in HFpEF, while pathways related to endoplasmic reticulum stress, autophagy, and angiogenesis were identified as downregulated genes specific to HFpEF.

CIRCULATION (2021)

Review Cardiac & Cardiovascular Systems

Cellular and molecular pathobiology of heart failure with preserved ejection fraction

Sumita Mishra et al.

Summary: Heart failure with preserved ejection fraction (HFpEF) is a complex multiorgan syndrome involving the heart, lungs, kidneys, skeletal muscle, adipose tissue, vascular system, and immune and inflammatory signaling. It is challenging to model in experimental animals due to its multiorgan involvement, but new animal models and efforts to examine human pathophysiology are revealing potential therapeutic targets. Research is focusing on cellular and molecular pathobiology of HFpEF, with efforts to understand mechanisms relevant to the heart as well as other organ systems, in order to develop more patient-specific therapies and improve clinical outcomes.

NATURE REVIEWS CARDIOLOGY (2021)

Article Cell Biology

IL-33 and Superantigenic Activation of Human Lung Mast Cells Induce the Release of Angiogenic and Lymphangiogenic Factors

Leonardo Cristinziano et al.

Summary: The study found that immunoglobulin superantigens protein A and protein L can induce rapid release of histamine from HLMCs, while IL-33 does not trigger histamine release from lung mast cells. Prolonged incubation of HLMCs with superantigens and IL-33 leads to the release of VEGF-A and VEGF-C. Preincubation with IL-33 enhances the superantigenic release of histamine, angiogenic and lymphangiogenic factors from HLMCs.

CELLS (2021)

Article Hematology

Mast Cells Are the Trigger of Small Vessel Disease and Diastolic Dysfunction in Diabetic Obese Mice

Sarah Guimbal et al.

Summary: Heart failure with preserved ejection fraction is a major health care issue with complex pathophysiology. This study demonstrates the critical role of cardiac small vessel disease in diastolic dysfunction, showing that mast cells participate in this process through histamine release, suggesting potential therapeutic targets.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Article Medicine, Research & Experimental

Vascular endothelial growth factors and angiopoietins as new players in mastocytosis

Simone Marcella et al.

Summary: Mastocytosis is characterized by abnormal proliferation of mast cells, often due to a gain-of-function mutation in the KIT receptor. Patients with mastocytosis show higher serum concentrations of VEGFs and ANGPTs, which are correlated with symptom severity.

CLINICAL AND EXPERIMENTAL MEDICINE (2021)

Review Pharmacology & Pharmacy

Angiopoietin inhibitors: A review on targeting tumor angiogenesis

Digna Parmar et al.

Summary: Angiogenesis is crucial for providing oxygen and nutrients to cells, but its imbalance can lead to pathological conditions. Tumor growth relies on angiogenesis for sustenance. Angiopoietins as alternative targets for anti-angiogenic therapy show promise, especially in combination with VEGF inhibitors.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Theresa A. McDonagh et al.

EUROPEAN HEART JOURNAL (2021)

Article Cell Biology

Human Lung-Resident Macrophages Express and Are Targets of Thymic Stromal Lymphopoietin in the Tumor Microenvironment

Mariantonia Braile et al.

Summary: TSLP is a pleiotropic cytokine that exerts its biological effects by binding to receptors and has been implicated in the induction and progression of various cancers. The TSLP system, expressed in lung macrophages, could play a role in chronic inflammatory disorders including lung cancer.

CELLS (2021)

Article Medicine, Research & Experimental

Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19

Alec A. Schmaier et al.

Summary: Endothelial dysfunction and changes in the Tie2/angiopoietin axis are associated with severe COVID-19, leading to a procoagulant state and potential harm to lung tissues. Primary endothelial cells treated with COVID-19 plasma exhibited a prothrombotic state, which was reversed by activation of Tie2 with AKB-9778.

JCI INSIGHT (2021)

Review Pharmacology & Pharmacy

IL-11 in cardiac and renal fibrosis: Late to the party but a central player

Benjamin Corden et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction

Julio A. Chirinos et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Medicine, General & Internal

Angiopoietins, Vascular Endothelial Growth Factors and Secretory Phospholipase A2in Ischemic and Non-Ischemic Heart Failure

Gilda Varricchi et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Cardiac & Cardiovascular Systems

Insight into the Pro-inflammatory and Profibrotic Role of Macrophage in Heart Failure With Preserved Ejection Fraction

Jin-lian Shen et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Angiopoietin 1 influences ischemic reperfusion renal injury via modulating endothelium survival and regeneration

Wen-Chih Chiang et al.

MOLECULAR MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

Heart Failure With Preserved Ejection Fraction In Perspective

Marc A. Pfeffer et al.

CIRCULATION RESEARCH (2019)

Review Allergy

Physiological Roles of Mast Cells: Collegium Internationale Allergologicum Update 2019

Gilda Varricchi et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Superantigenic Activation of Human Cardiac Mast Cells

Gilda Varricchi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Mast Cells, Angiogenesis and Lymphangiogenesis in Human Gastric Cancer

Giuseppe Sammarco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Nitrosative stress drives heart failure with preserved ejection fraction

Gabriele G. Schiattarella et al.

NATURE (2019)

Review Cell Biology

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

Racheal G. Akwii et al.

CELLS (2019)

Review Biochemistry & Molecular Biology

Future Needs in Mast Cell Biology

Gilda Varricchi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, General & Internal

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction

S. D. Solomon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Endocrinology & Metabolism

The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: A meta-analysis

Joseph Moxon et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)

Review Cardiac & Cardiovascular Systems

Adrenomedullin in heart failure: pathophysiology and therapeutic application

Adriaan A. Voors et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

Review Immunology

Innate effector cells in angiogenesis and lymphangiogenesis

Gilda Varricchi et al.

CURRENT OPINION IN IMMUNOLOGY (2018)

Article Immunology

Cardiac macrophages promote diastolic dysfunction

Maarten Hulsmans et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Review Medicine, Research & Experimental

Heart Failure with Preserved Ejection Fraction

James D. Gladden et al.

ANNUAL REVIEW OF MEDICINE, VOL 69 (2018)

Review Immunology

Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer

Gilda Varricchi et al.

FRONTIERS IN IMMUNOLOGY (2018)

Letter Hematology

Hereditary angioedema: the plasma contact system out of control: comment

S. Loffredo et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

Article Immunology

Secreted Phospholipases A2 in Hereditary Angioedema With C1-Inhibitor Deficiency

Stefania Loffredo et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Medicine, Research & Experimental

Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

Seung-Jun Lee et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Meeting Abstract Cardiac & Cardiovascular Systems

QRS duration is associated with outcome in symptomatic HF patients. What about ACCF/AHA stages A and B? Data from the DAVID-Berg study

A. Andrea Pozzi et al.

EUROPEAN JOURNAL OF HEART FAILURE (2018)

Review Medicine, Research & Experimental

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems

Lauri Eklund et al.

CLINICAL SCIENCE (2017)

Review Cardiac & Cardiovascular Systems

Epidemiology of heart failure with preserved ejection fraction

Shannon M. Dunlay et al.

NATURE REVIEWS CARDIOLOGY (2017)

Review Biotechnology & Applied Microbiology

Therapeutic targeting of the angiopoietin-TIE pathway

Pipsa Saharinen et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Cell Biology

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

Manuel Fankhauser et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Medicine, General & Internal

Effects of Percutaneous Coronary Intervention on Serum Angiopoietin-2 in Patients with Coronary Heart Disease

Zhi-Yu Zeng et al.

CHINESE MEDICAL JOURNAL (2016)

Review Cardiac & Cardiovascular Systems

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Piotr Ponikowski et al.

EUROPEAN HEART JOURNAL (2016)

Article Allergy

Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils

Teal S. Hallstrand et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Angiopoietin-2 in acute myocardial infarction complicated by cardiogenic shock-a biomarker substudy of the IABP-SHOCK II-Trial

Janine Poess et al.

EUROPEAN JOURNAL OF HEART FAILURE (2015)

Article Multidisciplinary Sciences

Cardiac lymphatics are heterogeneous in origin and respond to injury

Linda Klotz et al.

NATURE (2015)

Review Cardiac & Cardiovascular Systems

Heart Failure With Preserved Ejection Fraction Mechanisms, Clinical Features, and Therapies

Kavita Sharma et al.

CIRCULATION RESEARCH (2014)

Review Medicine, Research & Experimental

Lymphangiogenic factors, mechanisms, and applications

Wei Zheng et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Review Oncology

Lymphangiogenesis and lymphatic vessel remodelling in cancer

Steven A. Stacker et al.

NATURE REVIEWS CANCER (2014)

Review Biochemistry & Molecular Biology

Emerging roles of secreted phospholipase A2 enzymes: An update

Makoto Murakami et al.

BIOCHIMIE (2013)

Article Cardiac & Cardiovascular Systems

Circulating angiopoietins and cardiovascular mortality in cardiogenic shock

Andreas Link et al.

EUROPEAN HEART JOURNAL (2013)

Article Cardiac & Cardiovascular Systems

Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population

Roberto Lorbeer et al.

EUROPEAN JOURNAL OF HEART FAILURE (2013)

Review Cardiac & Cardiovascular Systems

Dilated cardiomyopathy: the complexity of a diverse genetic architecture

Ray E. Hershberger et al.

NATURE REVIEWS CARDIOLOGY (2013)

Article Multidisciplinary Sciences

Angiopoietin-2 in Adults with Congenital Heart Disease and Heart Failure

Alexander Lukasz et al.

PLOS ONE (2013)

Article Biotechnology & Applied Microbiology

AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy

Jenni Huusko et al.

MOLECULAR THERAPY (2012)

Review Cardiac & Cardiovascular Systems

Epidemiology and clinical course of heart failure with preserved ejection fraction

Carolyn S. P. Lam et al.

EUROPEAN JOURNAL OF HEART FAILURE (2011)

Article Biochemistry & Molecular Biology

Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer

Petra Schulz et al.

FASEB JOURNAL (2011)

Article Medicine, Research & Experimental

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

Marie Jeansson et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Biochemistry & Molecular Biology

The role of mast cell-derived secreted phospholipases A2 in respiratory allergy

Francescopaolo Granata et al.

BIOCHIMIE (2010)

Article Multidisciplinary Sciences

Pericytes are required for blood-brain barrier integrity during embryogenesis

Richard Daneman et al.

NATURE (2010)

Article Urology & Nephrology

Angiopoietin 2 and Cardiovascular Disease in Dialysis and Kidney Transplantation

Sascha David et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2009)

Article Allergy

Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects

Aikaterini Detoraki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

Article Allergy

Lung mast cells are a source of secreted phospholipases A(2)

Massimo Triggiani et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

Article Medicine, General & Internal

Angiopoietin-2 levels as a biomarker of cardiovascular risk in patients with hypertension

Jeetesh V. Patel et al.

ANNALS OF MEDICINE (2008)

Review Biochemistry & Molecular Biology

Biochemistry and physiology of mammalian secreted phospholipases A(2)

Gerard Lambeau et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2008)

Review Immunology

Angiopoietins: a link between angiogenesis and inflammation

Ulrike Fiedler et al.

TRENDS IN IMMUNOLOGY (2006)

Article Pharmacology & Pharmacy

Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage

F Roviezzo et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Cardiac & Cardiovascular Systems

Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure

AY Chong et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)

Article Cardiac & Cardiovascular Systems

Vascular endothelial growth factor-D expression in human atherosclerotic lesions

J Rutanen et al.

CARDIOVASCULAR RESEARCH (2003)

Article Cardiac & Cardiovascular Systems

Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions

JR Gamble et al.

CIRCULATION RESEARCH (2000)

Article Biochemistry & Molecular Biology

Angiopoietin-1 protects the adult vasculature against plasma leakage

G Thurston et al.

NATURE MEDICINE (2000)