Journal
EUROPEAN JOURNAL OF HEART FAILURE
Volume 24, Issue 12, Pages 2333-2341Publisher
WILEY
DOI: 10.1002/ejhf.2655
Keywords
Heart failure; Guided management; Remote monitoring; Telemonitoring; Hospitalization; Death
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Funding
- Universita Cattolica del Sacro Cuore within the CRUI-CARE Agreement
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This study aimed to evaluate whether device-based remote monitoring strategies guided by congestion markers are more effective than standard therapy for the management of worsening heart failure (HF). The findings showed that a haemodynamic-guided strategy was associated with a reduced risk of all-cause death and HF hospitalizations, while an impedance-guided strategy did not provide significant benefits.
Aims Pre-clinical congestion markers of worsening heart failure (HF) can be monitored by devices and may support the management of patients with HF. We aimed to assess whether congestion-guided HF management according to device-based remote monitoring strategies is more effective than standard therapy. Methods and results A comprehensive literature research for randomized controlled trials (RCTs) comparing device-based remote monitoring strategies for congestion-guided HF management versus standard therapy was performed on PubMed, Embase, and CENTRAL databases. Incidence rate ratios (IRRs) and associated 95% confidence intervals (CIs) were calculated using the Poisson regression model with random study effects. The primary outcome was a composite of all-cause death and HF hospitalizations. Secondary endpoints included the individual components of the primary outcome. A total of 4347 patients from eight RCTs were included. Findings varied according to the type of parameters monitored. Compared with standard therapy, haemodynamic-guided strategy (4 trials, 2224 patients, 12-month follow-up) reduced the risk of the primary composite outcome (IRR 0.79, 95% CI 0.70-0.89) and HF hospitalizations (IRR 0.76, 95% CI 0.67-0.86), without a significant impact on all-cause death (IRR 0.93, 95% CI 0.72-1.21). In contrast, impedance-guided strategy (4 trials, 2123 patients, 19-month follow-up) did not provide significant benefits. Conclusion Haemodynamic-guided HF management is associated with better clinical outcomes as compared to standard clinical care.
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