4.7 Article

Efficacy and safety of vorolanib plus everolimus in metastatic renal cell carcinoma: A three-arm, randomised, double-blind, multicentre phase III study (CONCEPT)

Related references

Note: Only part of the references are listed.
Article Oncology

Final Overall Survival and Molecular Analysis in IMmotion151, a Phase 3 Trial Comparing Atezolizumab Plus Bevacizumab vs Sunitinib in Patients With Previously Untreated Metastatic Renal Cell Carcinoma

Robert J. Motzer et al.

Summary: Interim analyses of the IMmotion151 trial showed improved progression-free survival for PD-L1-positive mRCC patients receiving atezolizumab plus bevacizumab vs sunitinib, but final analysis did not show improvement in overall survival. Biomarker analyses provided insight into which mRCC patients may benefit from combined anti-PD-L1 and anti-VEGF therapy.

JAMA ONCOLOGY (2022)

Article Oncology

Vorolanib, a novel tyrosine receptor kinase receptor inhibitor with potent preclinical anti-angiogenic and anti-tumor activity

Chris Liang et al.

Summary: Vorolanib is a novel multi-kinase receptor inhibitor that has potent antiangiogenic and anti-tumor activity, with lower toxicity compared to similar kinase inhibitors. It competitively binds and inhibits multiple tyrosine kinase receptors, inhibiting proliferation and tube formation of endothelial cells.

MOLECULAR THERAPY-ONCOLYTICS (2022)

Article Medicine, General & Internal

Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma

T. K. Choueiri et al.

Summary: The study demonstrates that nivolumab plus cabozantinib has significant advantages over sunitinib in the treatment of previously untreated advanced renal-cell carcinoma, including progression-free survival, overall survival, and likelihood of response.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma

Robert Motzer et al.

Summary: The study demonstrated that the combination of lenvatinib with pembrolizumab led to significantly longer progression-free survival and overall survival than sunitinib, while the combination of lenvatinib with everolimus showed longer progression-free survival but not overall survival compared to sunitinib. Adverse events were more frequent in patients receiving lenvatinib-based treatments.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

Brian I. Rini et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

R. J. Motzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

Treatment of renal cell carcinoma: Current status and future directions

Pedro C. Barata et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

Article Medicine, General & Internal

Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma

T. K. Choueiri et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

R. J. Motzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)