Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 96, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.etap.2022.103982
Keywords
Apoptosis; Flavonoids; Mycotoxins; Oxidative stress; PI3K; AKT pathway; PTEN
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This study found that the flavonoid quercetin can protect broiler chickens against nephrotoxicity induced by the mycotoxin ochratoxin A. Exposure to ochratoxin A resulted in increased levels of certain blood markers and decreased renal antioxidants, while coadministration of quercetin mitigated these toxic effects.
The mycotoxin ochratoxin A (OTA) is produced by the fungi Aspergillus and Penicillium. The flavonoid quercetin (QUE) is distinguished by its antioxidant, anti-inflammatory, and antiapoptotic properties. This study was designed to determine whether QUE can protect broiler chickens against OTA-induced nephrotoxicity. Forty broiler chicks were randomly divided into four equal groups: control, OTA, QUE, and OTA + QUE. For 6 weeks, OTA (0.5 mg/kg) and/or QUE (0.5 g/kg) were added to the diet of chickens. The results demonstrated that OTA exposure increased serum levels of creatinine, uric acid, and blood urea nitrogen. OTA exposure also increased renal malondialdehyde content but decreased renal antioxidants. OTA-exposed chickens exhibited multiple pathological kidney lesions. Moreover, OTA exposure induced apoptosis in renal tissue, which was manifested by the up-regulation of proapoptotic genes and down-regulation of antiapoptotic genes via the suppression of the PI3K/AKT pathway. In addition, coadministration of QUE and OTA mitigated most of these nephrotoxic effects.
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