Intensive endoscopic resection for downstaging of polyp burden in patients with familial adenomatous polyposis (J-FAPP Study III): a multicenter prospective interventional study

Article Gastroenterology & Hepatology

Prophylactic colectomy and rectal preservation in FAP: systematic endoscopic follow-up and adenoma destruction changes natural history of polyposis

Arnaud Pasquer et al.

Summary: The study analyzed 296 FAP patients who underwent prophylactic surgery and therapeutic endoscopic follow-up, comparing outcomes between IRA and IAA procedures. The results suggest that a combination of therapeutic endoscopic treatment and extended rectal preservation may be a safe alternative to ileoanal J-pouch anastomosis.

ENDOSCOPY INTERNATIONAL OPEN (2021)

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Article Gastroenterology & Hepatology

Efficacy and safety of ravidasvir plus sofosbuvir in patients with chronic hepatitis C infection without cirrhosis or with compensated cirrhosis (STORM-C-1): interim analysis of a two-stage, open-label, multicentre, single arm, phase 2/3 trial

Hideki Ishikawa et al.

Summary: In low-income and middle-income countries, there is an urgent need for affordable direct-acting antivirals to treat hepatitis C virus (HCV) infection. The combination of ravidasvir and sofosbuvir has shown efficacy and safety in patients with chronic HCV genotype 4 infection. The STORM-C-1 trial confirmed the effectiveness and tolerability of ravidasvir plus sofosbuvir in a diverse adult population with chronic HCV infection, providing a potential tool for large-scale implementation to eliminate HCV as a cause of morbidity and mortality.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Surgery